J 2008

The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats

BRIDGES, Nikola, Karel ŠLAIS and Eva SYKOVÁ

Basic information

Original name

The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats

Name in Czech

Vliv chronického podávání kortikosteronu na počet astrocytů v hipokampu: srovnání samců a samic potkana kmene Wistar

Authors

BRIDGES, Nikola (826 United Kingdom of Great Britain and Northern Ireland), Karel ŠLAIS (203 Czech Republic, guarantor) and Eva SYKOVÁ (203 Czech Republic)

Edition

Acta Neurobiologiae Experimentalis, Warsaw, Nencki Institute of Experimental Biology, 2008, 0065-1400

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.091

RIV identification code

RIV/00216224:14110/08:00026151

Organization unit

Faculty of Medicine

UT WoS

000258083200001

Keywords in English

astrocyte; corticosterone; hippocampus; rat; sex differences

Tags

Tags

International impact, Reviewed
Změněno: 23/6/2009 09:27, MUDr. Mgr. Karel Šlais, Ph.D.

Abstract

ORIG CZ

V originále

In the present study, we investigated the total percentage body weight, hippocampal volume and hippocampal astrocyte numbers following chronic corticosterone treatment in male and female Wistar rats. Males had greater left and right hippocampal volumes overall, but no effect on hippocampal volume was seen after corticosterone treatment. Total body weight was dose-dependently lower in both sexes, but the decrease was more prominent in male rats. Corticosterone treatment dose-dependently increased astrocyte numbers in the CA1 region, but not in the lateral and medial CA3 hippocampal regions. This increase was similar in both male and female rats.

In Czech

Tato práce studovala změny hmotnosti, velikosti hipokampu a počet astrocytů v hipokampu u samců a samic potkana kmene Wistar po dlouhodobém podávání kortikosteronu.

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.