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@inproceedings{770802,
author = {Pásek, Michal and Šimurda, Jiří},
address = {Prague},
booktitle = {Engineering Mechanics 2007},
edition = {1th ed.},
keywords = {cardiac cell; transverse-axial tubular system; tubular membrane area; quantitative modelling},
language = {eng},
location = {Prague},
isbn = {978-80-87012-06-2},
pages = {213-216},
publisher = {Institute of Thermomechanics AS CR},
title = {Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte},
year = {2007}
}
TY - JOUR
ID - 770802
AU - Pásek, Michal - Šimurda, Jiří
PY - 2007
TI - Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte
PB - Institute of Thermomechanics AS CR
CY - Prague
SN - 9788087012062
KW - cardiac cell
KW - transverse-axial tubular system
KW - tubular membrane area
KW - quantitative modelling
N2 - The transverse (t-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the t-tubule membrane. Despite their importance, the fraction of cell membrane within the t-tubules remains unclear: for example, measurement of cell capacitance following detubulation in rat cardiomyocytes suggests 32%, whereas optical measurements suggest up to 65%. We have therefore investigated the factors that may account for this discrepancy. Calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range.
ER -
PÁSEK, Michal and Jiří ŠIMURDA. Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte. In \textit{Engineering Mechanics 2007}. 1th ed. Prague: Institute of Thermomechanics AS CR, 2007, p.~213-216. ISBN~978-80-87012-06-2.
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