Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients

ŠPINAROVÁ, Lenka, Jindřich ŠPINAR, Anna VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ, Ondřej LUDKA, Josef TOMANDL and Jiří VÍTOVEC. Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. Experimental and Molecular Pathology. USA: The Human Press, 2008, vol. 84, No 7, p. 250-255. ISSN 0014-4800.

Basic information

• Original name: Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients
• Name in Czech: Genetika humorální a cytokinové aktivace u srdečního selhání a její význam pro stratifikaci rizika pacientů
• Authors: ŠPINAROVÁ, Lenka (203 Czech Republic, guarantor, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Ondřej LUDKA (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution) and Jiří VÍTOVEC (203 Czech Republic, belonging to the institution).
• Edition: Experimental and Molecular Pathology, USA, The Human Press, 2008, 0014-4800.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30201 Cardiac and Cardiovascular systems
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.930
• RIV identification code: RIV/00216224:14110/08:00026223
• Organization unit: Faculty of Medicine
• UT WoS: 000257725700011
• Keywords in English: Genetics;cytokines;chronic hear failure;stratification
• Tags: chronic hear failure, cytokines, genetics, stratification
• Tags: Reviewed

Abstract

Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. Patients with ischemic heart disease (IHD) and previous MI showed a difference in the distribution of genotype G8002A for endothelin-1: allele G 0.718 and A 0.282 vs those without MI: allele G 0.882 and A 0.118, (p < 0.05). Patients with IHD and DM had allele G in 0.67 and A 0.33, while those without DM had allele G in 0.790 and A in 0.209 (p < 0.03). Patients with IHD and concomitant PAD had allele G in 0.718 and A in 0.282 vs those without PAD allele G in 0.882 and A in 0.118 (p < 0.0004). Patients with dilative cardiomyopathy (DCMP) showed no differences in genotype G8002A and presence of DM or PAD. It might be speculated that in the case of endothelin-1 and TNF alpha in CHF the genetic determination is not important, and plasma concentrations are influenced more by the disease severity. Ischemics with previous MI, concomitant DM or PAD showed more frequently allele A and less often allele G than those without these diseases. A genotype with allele A is associated with higher risk of concomitant diseases.

Abstract (in Czech)

Genetika humorální a cytokinové aktivace u srdečního selhání a její význam pro stratifikaci rizika pacientů. Patients with ischemic heart disease (IHD) and previous MI showed a difference in the distribution of genotype G8002A for endothelin-1: allele G 0.718 and A 0.282 vs those without MI: allele G 0.882 and A 0.118, (p < 0.05). Patients with IHD and DM had allele G in 0.67 and A 0.33, while those without DM had allele G in 0.790 and A in 0.209 (p < 0.03). Patients with IHD and concomitant PAD had allele G in 0.718 and A in 0.282 vs those without PAD allele G in 0.882 and A in 0.118 (p < 0.0004). Patients with dilative cardiomyopathy (DCMP) showed no differences in genotype G8002A and presence of DM or PAD. It might be speculated that in the case of endothelin-1 and TNF alpha in CHF the genetic determination is not important, and plasma concentrations are influenced more by the disease severity. Ischemics with previous MI, concomitant DM or PAD showed more frequently allele A and less often allele G than those without these diseases. A genotype with allele A is associated with higher risk of concomitant diseases.

Links

• MSM0021622402, plan (intention): Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases