| YEGANEH, Mehdi, Philip HENNEKE, Nima REZAEI, Stephan EHL, Doerte THIEL, Nuria MATAMOROS, Cristina PIETROGRADA, Teresa ESPANOL, Jiří LITZMAN, Jose L. FRANCO, Ozden SANAL, Sara S. KILIC, Anna BREBOROWICZ, Alessandro BLEBANI, Ellen RENNER, Simon ROTHENFUSSER, Thomas R. RAWN, Cristina WOELLNER a Bodo GRIMBACHER. Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome. Online. International Archives Allergy and Immunology. Basel: Karger AG, 2008, roč. 146, č. 3, s. 190-194. ISSN 1018-2438. [citováno 2024-04-23] |
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@article{772327,
author = {Yeganeh, Mehdi and Henneke, Philip and Rezaei, Nima and Ehl, Stephan and Thiel, Doerte and Matamoros, Nuria and Pietrograda, Cristina and Espanol, Teresa and Litzman, Jiří and Franco, Jose L. and Sanal, Ozden and Kilic, Sara S. and Breborowicz, Anna and Blebani, Alessandro and Renner, Ellen and Rothenfusser, Simon and Rawn, Thomas R. and Woellner, Cristina and Grimbacher, Bodo},
article_location = {Basel},
article_number = {3},
keywords = {Hyper IgE syndrome; Toll-like receptor;TNF alpha},
language = {eng},
issn = {1018-2438},
journal = {International Archives Allergy and Immunology},
title = {Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.},
volume = {146},
year = {2008}
}
TY - JOUR
ID - 772327
AU - Yeganeh, Mehdi - Henneke, Philip - Rezaei, Nima - Ehl, Stephan - Thiel, Doerte - Matamoros, Nuria - Pietrograda, Cristina - Espanol, Teresa - Litzman, Jiří - Franco, Jose L. - Sanal, Ozden - Kilic, Sara S. - Breborowicz, Anna - Blebani, Alessandro - Renner, Ellen - Rothenfusser, Simon - Rawn, Thomas R. - Woellner, Cristina - Grimbacher, Bodo
PY - 2008
TI - Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.
JF - International Archives Allergy and Immunology
VL - 146
IS - 3
SP - 190-194
EP - 190-194
PB - Karger AG
SN - 10182438
KW - Hyper IgE syndrome
KW - Toll-like receptor;TNF alpha
N2 - Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES.
ER -
YEGANEH, Mehdi, Philip HENNEKE, Nima REZAEI, Stephan EHL, Doerte THIEL, Nuria MATAMOROS, Cristina PIETROGRADA, Teresa ESPANOL, Jiří LITZMAN, Jose L. FRANCO, Ozden SANAL, Sara S. KILIC, Anna BREBOROWICZ, Alessandro BLEBANI, Ellen RENNER, Simon ROTHENFUSSER, Thomas R. RAWN, Cristina WOELLNER a Bodo GRIMBACHER. Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome. Online. \textit{International Archives Allergy and Immunology}. Basel: Karger AG, 2008, roč.~146, č.~3, s.~190-194. ISSN~1018-2438. [citováno 2024-04-23]
|
