Toll-like receptor stimulation induces higher TNF-alpha
secretion in peripheral blood mononuclear cells from patients
with hyper IgE syndrome.

J 2008

Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.

YEGANEH, Mehdi, Philip HENNEKE, Nima REZAEI, Stephan EHL, Doerte THIEL et. al.

Basic information

Original name

Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.

Name in Czech

Stimulace Toll-like receptorů periferních mononukleárů pacientů s hyper IgE syndromem vede k tvorbě TNF alfa

Authors

YEGANEH, Mehdi (364 Islamic Republic of Iran), Philip HENNEKE (276 Germany), Nima REZAEI (364 Islamic Republic of Iran), Stephan EHL (276 Germany), Doerte THIEL (276 Germany), Nuria MATAMOROS (724 Spain), Cristina PIETROGRADA (380 Italy), Teresa ESPANOL (724 Spain), Jiří LITZMAN (203 Czech Republic, guarantor), Jose L. FRANCO (170 Colombia), Ozden SANAL (792 Turkey), Sara S. KILIC (792 Turkey), Anna BREBOROWICZ (792 Turkey), Alessandro BLEBANI (380 Italy), Ellen RENNER (276 Germany), Simon ROTHENFUSSER (276 Germany), Thomas R. RAWN (840 United States of America), Cristina WOELLNER (826 United Kingdom of Great Britain and Northern Ireland) and Bodo GRIMBACHER (826 United Kingdom of Great Britain and Northern Ireland)

Edition

International Archives Allergy and Immunology, Basel, Karger AG, 2008, 1018-2438

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.131

RIV identification code

RIV/00216224:14110/08:00028225

Organization unit

Faculty of Medicine

UT WoS

000255896000002

Keywords in English

Hyper IgE syndrome; Toll-like receptor;TNF alpha

Abstract

ORIG CZ

V originále

Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES.

In Czech

Stimulace Toll-like receptorů periferních mononukleárů pacientů s hyper IgE syndromem vede k tvorbě TNF alfa

Links

NR9192, research and development project

Name: Screening mutací a polymorfismů v genu pro neonatální Fc receptor u pacientů s primárními poruchami tvorby protilátek

Citovat

YEGANEH, Mehdi, Philip HENNEKE, Nima REZAEI, Stephan EHL, Doerte THIEL, Nuria MATAMOROS, Cristina PIETROGRADA, Teresa ESPANOL, Jiří LITZMAN, Jose L. FRANCO, Ozden SANAL, Sara S. KILIC, Anna BREBOROWICZ, Alessandro BLEBANI, Ellen RENNER, Simon ROTHENFUSSER, Thomas R. RAWN, Cristina WOELLNER and Bodo GRIMBACHER. Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome. International Archives Allergy and Immunology. Basel: Karger AG, 2008, vol. 146, No 3, p. 190-194. ISSN 1018-2438.

@article{772327,
   author = {Yeganeh, Mehdi and Henneke, Philip and Rezaei, Nima and Ehl, Stephan and Thiel, Doerte and Matamoros, Nuria and Pietrograda, Cristina and Espanol, Teresa and Litzman, Jiří and Franco, Jose L. and Sanal, Ozden and Kilic, Sara S. and Breborowicz, Anna and Blebani, Alessandro and Renner, Ellen and Rothenfusser, Simon and Rawn, Thomas R. and Woellner, Cristina and Grimbacher, Bodo},
   article_location = {Basel},
   article_number = {3},
   keywords = {Hyper IgE syndrome; Toll-like receptor;TNF alpha},
   language = {eng},
   issn = {1018-2438},
   journal = {International Archives Allergy and Immunology},
   title = {Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.},
   volume = {146},
   year = {2008}
}

TY  - JOUR
ID  - 772327
AU  - Yeganeh, Mehdi - Henneke, Philip - Rezaei, Nima - Ehl, Stephan - Thiel, Doerte - Matamoros, Nuria - Pietrograda, Cristina - Espanol, Teresa - Litzman, Jiří - Franco, Jose L. - Sanal, Ozden - Kilic, Sara S. - Breborowicz, Anna - Blebani, Alessandro - Renner, Ellen - Rothenfusser, Simon - Rawn, Thomas R. - Woellner, Cristina - Grimbacher, Bodo
PY  - 2008
TI  - Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.
JF  - International Archives Allergy and Immunology
VL  - 146
IS  - 3
SP  - 190-194
EP  - 190-194
PB  - Karger AG
SN  - 10182438
KW  - Hyper IgE syndrome
KW  - Toll-like receptor;TNF alpha
N2  - Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES.
ER  -

YEGANEH, Mehdi, Philip HENNEKE, Nima REZAEI, Stephan EHL, Doerte THIEL, Nuria MATAMOROS, Cristina PIETROGRADA, Teresa ESPANOL, Jiří LITZMAN, Jose L. FRANCO, Ozden SANAL, Sara S. KILIC, Anna BREBOROWICZ, Alessandro BLEBANI, Ellen RENNER, Simon ROTHENFUSSER, Thomas R. RAWN, Cristina WOELLNER and Bodo GRIMBACHER. Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome. \textit{International Archives Allergy and Immunology}. Basel: Karger AG, 2008, vol.~146, No~3, p.~190-194. ISSN~1018-2438.

Detailed Information on Publication Record