Environmental (Ecological) and Human Risk Assessment (EcoHRA) is a complex process of assessing the influence of human activities on ecosystem duality and vice versa. The endpoint of EcoHRA is a prospective or retrospective assessment of stress factors influence (chemical contaminants, anthropogenic interventions or natural disasters) on ecosystems and their parts. Monitoring and collecting of available information as the source data for EcoHRA is a key part of the process for the assessor. Recent development of information and communication technologies provides very powerful platforms for effective processing of multiple data sources. Particularly, web searches, database systems and data mining tools oriented on key environmental components and their descriptors, regionally-specific data aggregation, mapping of exposure and segmentation of the region of interest using Geographic Information Systems technology, automated processing of laboratory tests, namely dose-response curves using eco-toxicologically relevant models, algorithms and statistical packages and probabilistic estimates of risk level and associated uncertainties and their reflection in standardization of used environmental information systems by EEA, EPA, OECD and UNEP.