Subepicardial phase 0 block and discontinuous transmural
conduction underlie right precordial ST-segment elevation by a
SCN5A loss-of-function mutation

J 2008

Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation

BÉBAROVÁ, Markéta, Tom 0´HARA, Jan GEELEN, Roselie JONGBLOED, Carl TIMMERMANS et. al.

Basic information

Original name

Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation

Name in Czech

Subepikardiální blokáda ve fázi 0 a přerušené transmurální šíření vyvolané mutací vyznačující se ztrátou funkce SCN5A genu jsou podkladem elevace ST-segmentu v pravém prekordiu

Authors

BÉBAROVÁ, Markéta, Tom 0´HARA, Jan GEELEN, Roselie JONGBLOED, Carl TIMMERMANS, Yvonne ARENS, Luz-Maria RODRIGUEZ, Yoram RUDY and Paul VOLDERS

Edition

American Journal of Physiology - Heart and Circulatory Physiology, 2008, 0363-6135

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.643

Organization unit

Faculty of Medicine

UT WoS

000257593800008

Keywords in English

Brugada syndrome; mutation; patch clamp; cell lines; arrhythmogenesis

Abstract

ORIG CZ

V originále

Our data may explain ST-segment elevation on the basis of massive transmural voltage gradients during early repolarization. Reentry-based tachycardia could be evoked during conditions that further exaggerate conduction block in this Brugada phenotype.

In Czech

Naše data mohou ST elevaci vysvětlit na podkladě masivního transmurálního napěťového gradientu během časné repolarizace. Tachykardie založená na mechanismu reentry může být vyvolána za podmínek, které dále zhoršují blokádu vedení u tohoto fenotypu.

Citovat

BÉBAROVÁ, Markéta, Tom 0´HARA, Jan GEELEN, Roselie JONGBLOED, Carl TIMMERMANS, Yvonne ARENS, Luz-Maria RODRIGUEZ, Yoram RUDY and Paul VOLDERS. Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation. American Journal of Physiology - Heart and Circulatory Physiology. 2008, vol. 295, No 1, p. H48-H58, 10 pp. ISSN 0363-6135.

@article{772761,
   author = {Bébarová, Markéta and 0´Hara, Tom and Geelen, Jan and Jongbloed, Roselie and Timmermans, Carl and Arens, Yvonne and Rodriguez, LuzandMaria and Rudy, Yoram and Volders, Paul},
   article_number = {1},
   keywords = {Brugada syndrome; mutation; patch clamp; cell lines; arrhythmogenesis},
   language = {eng},
   issn = {0363-6135},
   journal = {American Journal of Physiology - Heart and Circulatory Physiology},
   title = {Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation},
   volume = {295},
   year = {2008}
}

TY  - JOUR
ID  - 772761
AU  - Bébarová, Markéta - 0´Hara, Tom - Geelen, Jan - Jongbloed, Roselie - Timmermans, Carl - Arens, Yvonne - Rodriguez, Luz-Maria - Rudy, Yoram - Volders, Paul
PY  - 2008
TI  - Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation
JF  - American Journal of Physiology - Heart and Circulatory Physiology
VL  - 295
IS  - 1
SP  - H48-H58
EP  - H48-H58
SN  - 03636135
KW  - Brugada syndrome
KW  - mutation
KW  - patch clamp
KW  - cell lines
KW  - arrhythmogenesis
N2  - Our data may explain ST-segment elevation on the basis of massive transmural voltage gradients during early repolarization. Reentry-based tachycardia could be evoked during conditions that further exaggerate conduction block in this Brugada phenotype.
ER  -

BÉBAROVÁ, Markéta, Tom 0´HARA, Jan GEELEN, Roselie JONGBLOED, Carl TIMMERMANS, Yvonne ARENS, Luz-Maria RODRIGUEZ, Yoram RUDY and Paul VOLDERS. Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation. \textit{American Journal of Physiology - Heart and Circulatory Physiology}. 2008, vol.~295, No~1, p.~H48-H58, 10 pp. ISSN~0363-6135.

Detailed Information on Publication Record