Detailed Information on Publication Record

ŠLAIS, Karel and Alexandra ŠULCOVÁ. Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice. The International Journal of Neuropsychopharmacology. Cambridge: Cambridge University Press, 2008, vol. 11, Supp 1, p. 235. ISSN 1461-1457.

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Basic information
Original name	Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice
Name in Czech	Účinky inhibitoru zpětného vstřebávání anandamidu O-2093 na agresivitu u myší
Authors	ŠLAIS, Karel and Alexandra ŠULCOVÁ.
Edition	The International Journal of Neuropsychopharmacology, Cambridge, Cambridge University Press, 2008, 1461-1457.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30104 Pharmacology and pharmacy
Country of publisher	United Kingdom of Great Britain and Northern Ireland
Confidentiality degree	is not subject to a state or trade secret
Impact factor	Impact factor: 4.378
Organization unit	Faculty of Medicine
UT WoS	000258855501258
Keywords in English	O-2093; aggressivity; mouse; behaviour
Tags	aggressivity, behaviour, mouse, O-2093
Tags	International impact
Changed by	Changed by: MUDr. Mgr. Karel Šlais, Ph.D., učo 19989. Changed: 24/6/2009 13:10.

Abstract
Testing effects of endocannabinoid anandamide on mouse behaviour on paired conflict social interactions we have found its inhibitory influence on aggressive activities in aggressive isolates and pro-aggressive effects in timid mice exhibiting on control interaction defensive-escape behaviour but no attacks. The aim of this study was to ascertain if the anandamide uptake inhibitor O-2093 can elicit similar behavioural changes on mouse agonist behaviour as anandamide as well as other cannabinoid receptor agonist previously tested (HU-210, methanandamide).In timid mice (n=11), all doses of O-2093 tested caused significant increase of aggressive behavioural acts (tail rattling, unrest, attack of the partner). We observed no changes in behaviour of aggressive mice. The present findings confirmed that inhibition of anandamide uptake is able to produce analogical pro-aggressive effects as administration of anandamide in mice showing on social conflict timidity. On the contrary, the suspected enhanced physiological effect of anandamide after administration of its uptake inhibitor was insufficient to produced reduction of aggressive activities in aggressive singly-housed mice measured earlier after exogenously given anadamide.

Abstract

Testing effects of endocannabinoid anandamide on mouse behaviour on paired conflict social interactions we have found its inhibitory influence on aggressive activities in aggressive isolates and pro-aggressive effects in timid mice exhibiting on control interaction defensive-escape behaviour but no attacks. The aim of this study was to ascertain if the anandamide uptake inhibitor O-2093 can elicit similar behavioural changes on mouse agonist behaviour as anandamide as well as other cannabinoid receptor agonist previously tested (HU-210, methanandamide).In timid mice (n=11), all doses of O-2093 tested caused significant increase of aggressive behavioural acts (tail rattling, unrest, attack of the partner). We observed no changes in behaviour of aggressive mice. The present findings confirmed that inhibition of anandamide uptake is able to produce analogical pro-aggressive effects as administration of anandamide in mice showing on social conflict timidity. On the contrary, the suspected enhanced physiological effect of anandamide after administration of its uptake inhibitor was insufficient to produced reduction of aggressive activities in aggressive singly-housed mice measured earlier after exogenously given anadamide.

Abstract (in Czech)
Práce popisuje účinky inhibitoru zpětného vychytávání anandamidu O-2093 na agresivitu v testu agonistických interakcí samostatně chovaných myších samců se skupinově ustájenými zvířaty. Po podání O-2093 bylo prokázáno zvášení agresivity u plachých myší.

Links
MSM0021622404, plan (intention)	Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
MSM0021622404, plan (intention)	Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.