Effect of anandamide uptake inhibitor O-2093 on aggressivity in
mice

J 2008

Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice

ŠLAIS, Karel and Alexandra ŠULCOVÁ

Basic information

Original name

Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice

Name in Czech

Účinky inhibitoru zpětného vstřebávání anandamidu O-2093 na agresivitu u myší

Authors

ŠLAIS, Karel and Alexandra ŠULCOVÁ

Edition

The International Journal of Neuropsychopharmacology, Cambridge, Cambridge University Press, 2008, 1461-1457

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.378

Organization unit

Faculty of Medicine

UT WoS

000258855501258

Keywords in English

O-2093; aggressivity; mouse; behaviour

Abstract

ORIG CZ

V originále

Testing effects of endocannabinoid anandamide on mouse behaviour on paired conflict social interactions we have found its inhibitory influence on aggressive activities in aggressive isolates and pro-aggressive effects in timid mice exhibiting on control interaction defensive-escape behaviour but no attacks. The aim of this study was to ascertain if the anandamide uptake inhibitor O-2093 can elicit similar behavioural changes on mouse agonist behaviour as anandamide as well as other cannabinoid receptor agonist previously tested (HU-210, methanandamide).In timid mice (n=11), all doses of O-2093 tested caused significant increase of aggressive behavioural acts (tail rattling, unrest, attack of the partner). We observed no changes in behaviour of aggressive mice. The present findings confirmed that inhibition of anandamide uptake is able to produce analogical pro-aggressive effects as administration of anandamide in mice showing on social conflict timidity. On the contrary, the suspected enhanced physiological effect of anandamide after administration of its uptake inhibitor was insufficient to produced reduction of aggressive activities in aggressive singly-housed mice measured earlier after exogenously given anadamide.

In Czech

Práce popisuje účinky inhibitoru zpětného vychytávání anandamidu O-2093 na agresivitu v testu agonistických interakcí samostatně chovaných myších samců se skupinově ustájenými zvířaty. Po podání O-2093 bylo prokázáno zvášení agresivity u plachých myší.

Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

ŠLAIS, Karel and Alexandra ŠULCOVÁ. Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice. The International Journal of Neuropsychopharmacology. Cambridge: Cambridge University Press, 2008, vol. 11, Supp 1, p. 235. ISSN 1461-1457.

@article{772778,
   author = {Šlais, Karel and Šulcová, Alexandra},
   article_location = {Cambridge},
   article_number = {Supp 1},
   keywords = {O-2093; aggressivity; mouse; behaviour},
   language = {eng},
   issn = {1461-1457},
   journal = {The International Journal of Neuropsychopharmacology},
   title = {Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice},
   volume = {11},
   year = {2008}
}

TY  - JOUR
ID  - 772778
AU  - Šlais, Karel - Šulcová, Alexandra
PY  - 2008
TI  - Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice
JF  - The International Journal of Neuropsychopharmacology
VL  - 11
IS  - Supp 1
SP  - 235
EP  - 235
PB  - Cambridge University Press
SN  - 14611457
KW  - O-2093
KW  - aggressivity
KW  - mouse
KW  - behaviour
N2  - Testing effects of endocannabinoid anandamide on mouse behaviour on paired conflict social interactions we have found its inhibitory influence on aggressive activities in aggressive isolates and pro-aggressive effects in timid mice exhibiting on control interaction defensive-escape behaviour but no attacks. The aim of this study was to ascertain if the anandamide uptake inhibitor O-2093 can elicit similar behavioural changes on mouse agonist behaviour as anandamide as well as other cannabinoid receptor agonist previously tested (HU-210, methanandamide).In timid mice (n=11), all doses of O-2093 tested caused significant increase of aggressive behavioural acts (tail rattling, unrest, attack of the partner). We observed no changes in behaviour of aggressive mice. The present findings confirmed that inhibition of anandamide uptake is able to produce analogical pro-aggressive effects as administration of anandamide in mice showing on social conflict timidity. On the contrary, the suspected enhanced physiological effect of anandamide after administration of its uptake inhibitor was insufficient to produced reduction of aggressive activities in aggressive singly-housed mice measured earlier after exogenously given anadamide.
ER  -

ŠLAIS, Karel and Alexandra ŠULCOVÁ. Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice. \textit{The International Journal of Neuropsychopharmacology}. Cambridge: Cambridge University Press, 2008, vol.~11, Supp 1, p.~235. ISSN~1461-1457.

Detailed Information on Publication Record