Mechanical response of porous scaffolds for cartilage
engineering

J 2007

Mechanical response of porous scaffolds for cartilage engineering

JANČÁŘ, Josef, Alexandra SLOVIKOVA, Evžen AMLER, Petr KRUPA, Helga KECOVÁ et. al.

Basic information

Original name

Mechanical response of porous scaffolds for cartilage engineering

Name in Czech

Mechanická odpověď porózního skafoldu pro zpracování chrupavek.

Authors

JANČÁŘ, Josef (203 Czech Republic, guarantor), Alexandra SLOVIKOVA (203 Czech Republic), Evžen AMLER (203 Czech Republic), Petr KRUPA (203 Czech Republic), Helga KECOVÁ (203 Czech Republic), Ladislav PLÁNKA (203 Czech Republic), Petr GÁL (203 Czech Republic) and Alois NEČAS (203 Czech Republic)

Edition

Physiological Research, Praha, Inst. of Physiol., Academy of Sciences, 2007, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30211 Orthopaedics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.505

RIV identification code

RIV/00216224:14110/07:00024236

Organization unit

Faculty of Medicine

UT WoS

000252436800003

Keywords in English

Chitosan; Nanofibers; Hyaluronic acid; Hydroxyapatite; Mesenchymal stem cells; Joint resurfacing

Abstract

ORIG CZ

V originále

In this paper, the effect of modification of the cross-linked collagen I with hyaluronic acid, hydroxyapatite nanoparticles and chitosan nanofibers on the mechanical response of the compact scaffold material and the lyophilized porous scaffold construct has been investigated in the dry state at 37 oC under tensile loading. The results showed that the addition of hyaluronic acid reduced the tensile elastic modulus and slightly increased the ultimate deformation of crosslinked collagen I under the test conditions used. On the other hand, addition of hydroxyapatite nanoparticles and chitosan nanofibers, respectively, increased the elastic modulus of the modified collagen ten-fold and four-fold, respectively. The ultimate tensile deformation has been decreased by hydroxyapatite and increased by the chitosan nanofibers. It can be concluded that enhancing the stiffness of the compact scaffold material by adding rigid chitosan nanofibers can improve the resistance of the porous scaffolds against mechanical loading. SEM micrographs revealed the effect of the respective additives on the pore structure of the lyophilized collagen foams. lagen modified with chitosan nanofibers exhibited the most uniform pore structure. Moreover, chitosan nanofibers seemed to enhance mesenchymal cell growth compared to neat collagen I.

In Czech

grgrgwg

Links

MSM0021630501, plan (intention)

Name: Multifunkční heterogenní materiály na bázi syntetických polymerů a biopolymerů

2B06130, research and development project

Name: Využití nově syntetizovaných biomateriálů v kombinaci s kmenovými buňkami v léčbě chorob, které postihují lidské tkáně derivované z mesodermu: chrupavku, kost, vazy a menisky. (Acronym: Chondros)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

JANČÁŘ, Josef, Alexandra SLOVIKOVA, Evžen AMLER, Petr KRUPA, Helga KECOVÁ, Ladislav PLÁNKA, Petr GÁL and Alois NEČAS. Mechanical response of porous scaffolds for cartilage engineering. Physiological Research. Praha: Inst. of Physiol., Academy of Sciences, 2007, vol. 56, Suppl. 1, p. S17-S25, 9 pp. ISSN 0862-8408.

@article{773193,
   author = {Jančář, Josef and Slovikova, Alexandra and Amler, Evžen and Krupa, Petr and Kecová, Helga and Plánka, Ladislav and Gál, Petr and Nečas, Alois},
   article_location = {Praha},
   article_number = {Suppl. 1},
   keywords = {Chitosan; Nanofibers; Hyaluronic acid; Hydroxyapatite; Mesenchymal stem cells; Joint resurfacing},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Mechanical response of porous scaffolds for cartilage engineering},
   volume = {56},
   year = {2007}
}

TY  - JOUR
ID  - 773193
AU  - Jančář, Josef - Slovikova, Alexandra - Amler, Evžen - Krupa, Petr - Kecová, Helga - Plánka, Ladislav - Gál, Petr - Nečas, Alois
PY  - 2007
TI  - Mechanical response of porous scaffolds for cartilage engineering
JF  - Physiological Research
VL  - 56
IS  - Suppl. 1
SP  - S17-S25
EP  - S17-S25
PB  - Inst. of Physiol., Academy of Sciences
SN  - 08628408
KW  - Chitosan
KW  - Nanofibers
KW  - Hyaluronic acid
KW  - Hydroxyapatite
KW  - Mesenchymal stem cells
KW  - Joint resurfacing
N2  - In this paper, the effect of modification of the cross-linked collagen I with hyaluronic acid, hydroxyapatite nanoparticles and chitosan nanofibers on the mechanical response of the compact scaffold material and the lyophilized porous scaffold construct has been investigated in the dry state at 37 oC under tensile loading. The results showed that the addition of hyaluronic acid reduced the tensile elastic modulus and slightly increased the ultimate deformation of crosslinked collagen I under the test conditions used. On the other hand, addition of hydroxyapatite nanoparticles and chitosan nanofibers, respectively, increased the elastic modulus of the modified collagen ten-fold and four-fold, respectively. The ultimate tensile deformation has been decreased by hydroxyapatite and increased by the chitosan nanofibers. It can be concluded that enhancing the stiffness of the compact scaffold material by adding rigid chitosan nanofibers can improve the resistance of the porous scaffolds against mechanical loading. SEM micrographs revealed the effect of the respective additives on the pore structure of the lyophilized collagen foams. lagen modified with chitosan nanofibers exhibited the most uniform pore structure. Moreover, chitosan nanofibers seemed to enhance mesenchymal cell growth compared to neat collagen I.
ER  -

JANČÁŘ, Josef, Alexandra SLOVIKOVA, Evžen AMLER, Petr KRUPA, Helga KECOVÁ, Ladislav PLÁNKA, Petr GÁL and Alois NEČAS. Mechanical response of porous scaffolds for cartilage engineering. \textit{Physiological Research}. Praha: Inst. of Physiol., Academy of Sciences, 2007, vol.~56, Suppl. 1, p.~S17-S25, 9 pp. ISSN~0862-8408.

Detailed Information on Publication Record