| XU, Guogang, Maryane HERZIG, Vladimír ROTREKL a Christi, A. WALTER. Base excision repair, aging and health span. Mechanisms of ageing and development. Ireland: Elsevier Science Ireland, roč. 129, 7-8, s. 366-382. ISSN 0047-6374. doi:10.1016/j.mad.2008.03.001. 2008. |
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@article{773202,
author = {Xu, Guogang and Herzig, Maryane and Rotrekl, Vladimír and Walter, Christi, A.},
article_location = {Ireland},
article_number = {7-8},
doi = {http://dx.doi.org/10.1016/j.mad.2008.03.001},
keywords = {Base excision repair; Aging; DNA damage; Mutagenesis; Health span},
language = {eng},
issn = {0047-6374},
journal = {Mechanisms of ageing and development},
title = {Base excision repair, aging and health span},
url = {https://www.sciencedirect.com/science/article/pii/S0047637408000675?via%3Dihub},
volume = {129},
year = {2008}
}
TY - JOUR
ID - 773202
AU - Xu, Guogang - Herzig, Maryane - Rotrekl, Vladimír - Walter, Christi, A.
PY - 2008
TI - Base excision repair, aging and health span
JF - Mechanisms of ageing and development
VL - 129
IS - 7-8
SP - 366-382
EP - 366-382
PB - Elsevier Science Ireland
SN - 00476374
KW - Base excision repair
KW - Aging
KW - DNA damage
KW - Mutagenesis
KW - Health span
UR - https://www.sciencedirect.com/science/article/pii/S0047637408000675?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S0047637408000675?via%3Dihub
N2 - DNA damage and mutagenesis are suggested to contribute to aging through their ability to mediate cellular dysfunction. The base excision repair (BER) pathway ameliorates a large number of DNA lesions that arise spontaneously. Many of these lesions are reported to increase with age. The specific BER protein that appears to limit activity varies among tissues. DNA polymerase-beta is reduced in brain from aged mice and rats while AP endonuclease is reduced in spermatogenic cells obtained from old mice. The differences in proteins that appear to limit BER activity among tissues may represent true tissue-specific differences in activity or may be due to differences in techniques, environmental conditions or other unidentified differences among the experimental approaches. Much remains to be addressed concerning the potential role of BER in aging and age-related health span.
ER -
XU, Guogang, Maryane HERZIG, Vladimír ROTREKL a Christi, A. WALTER. Base excision repair, aging and health span. \textit{Mechanisms of ageing and development}. Ireland: Elsevier Science Ireland, roč.~129, 7-8, s.~366-382. ISSN~0047-6374. doi:10.1016/j.mad.2008.03.001. 2008.
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