XU, Guogang, Maryane HERZIG, Vladimír ROTREKL and Christi, A. WALTER. Base excision repair, aging and health span. Mechanisms of ageing and development. Ireland: Elsevier Science Ireland, 2008, vol. 129, 7-8, p. 366-382. ISSN 0047-6374. Available from: https://dx.doi.org/10.1016/j.mad.2008.03.001. |
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@article{773202, author = {Xu, Guogang and Herzig, Maryane and Rotrekl, Vladimír and Walter, Christi, A.}, article_location = {Ireland}, article_number = {7-8}, doi = {http://dx.doi.org/10.1016/j.mad.2008.03.001}, keywords = {Base excision repair; Aging; DNA damage; Mutagenesis; Health span}, language = {eng}, issn = {0047-6374}, journal = {Mechanisms of ageing and development}, title = {Base excision repair, aging and health span}, url = {https://www.sciencedirect.com/science/article/pii/S0047637408000675?via%3Dihub}, volume = {129}, year = {2008} }
TY - JOUR ID - 773202 AU - Xu, Guogang - Herzig, Maryane - Rotrekl, Vladimír - Walter, Christi, A. PY - 2008 TI - Base excision repair, aging and health span JF - Mechanisms of ageing and development VL - 129 IS - 7-8 SP - 366-382 EP - 366-382 PB - Elsevier Science Ireland SN - 00476374 KW - Base excision repair KW - Aging KW - DNA damage KW - Mutagenesis KW - Health span UR - https://www.sciencedirect.com/science/article/pii/S0047637408000675?via%3Dihub L2 - https://www.sciencedirect.com/science/article/pii/S0047637408000675?via%3Dihub N2 - DNA damage and mutagenesis are suggested to contribute to aging through their ability to mediate cellular dysfunction. The base excision repair (BER) pathway ameliorates a large number of DNA lesions that arise spontaneously. Many of these lesions are reported to increase with age. The specific BER protein that appears to limit activity varies among tissues. DNA polymerase-beta is reduced in brain from aged mice and rats while AP endonuclease is reduced in spermatogenic cells obtained from old mice. The differences in proteins that appear to limit BER activity among tissues may represent true tissue-specific differences in activity or may be due to differences in techniques, environmental conditions or other unidentified differences among the experimental approaches. Much remains to be addressed concerning the potential role of BER in aging and age-related health span. ER -
XU, Guogang, Maryane HERZIG, Vladimír ROTREKL and Christi, A. WALTER. Base excision repair, aging and health span. \textit{Mechanisms of ageing and development}. Ireland: Elsevier Science Ireland, 2008, vol.~129, 7-8, p.~366-382. ISSN~0047-6374. Available from: https://dx.doi.org/10.1016/j.mad.2008.03.001.
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