Base excision repair, aging and health span

J 2008

Base excision repair, aging and health span

XU, Guogang, Maryane HERZIG, Vladimír ROTREKL and Christi, A. WALTER

Basic information

Original name

Base excision repair, aging and health span

Name in Czech

Bázově excizní oprava, stárnutí a délka života

Authors

XU, Guogang (156 China), Maryane HERZIG (840 United States of America), Vladimír ROTREKL (203 Czech Republic, guarantor, belonging to the institution) and Christi, A. WALTER (840 United States of America)

Edition

Mechanisms of ageing and development, Ireland, Elsevier Science Ireland, 2008, 0047-6374

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.915

RIV identification code

RIV/00216224:14110/08:00107021

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.mad.2008.03.001

UT WoS

000257816100003

Keywords in English

Base excision repair; Aging; DNA damage; Mutagenesis; Health span

Abstract

V originále

DNA damage and mutagenesis are suggested to contribute to aging through their ability to mediate cellular dysfunction. The base excision repair (BER) pathway ameliorates a large number of DNA lesions that arise spontaneously. Many of these lesions are reported to increase with age. The specific BER protein that appears to limit activity varies among tissues. DNA polymerase-beta is reduced in brain from aged mice and rats while AP endonuclease is reduced in spermatogenic cells obtained from old mice. The differences in proteins that appear to limit BER activity among tissues may represent true tissue-specific differences in activity or may be due to differences in techniques, environmental conditions or other unidentified differences among the experimental approaches. Much remains to be addressed concerning the potential role of BER in aging and age-related health span.

Citovat

XU, Guogang, Maryane HERZIG, Vladimír ROTREKL and Christi, A. WALTER. Base excision repair, aging and health span. Mechanisms of ageing and development. Ireland: Elsevier Science Ireland, 2008, vol. 129, 7-8, p. 366-382. ISSN 0047-6374. Available from: https://dx.doi.org/10.1016/j.mad.2008.03.001.

@article{773202,
   author = {Xu, Guogang and Herzig, Maryane and Rotrekl, Vladimír and Walter, Christi, A.},
   article_location = {Ireland},
   article_number = {7-8},
   doi = {http://dx.doi.org/10.1016/j.mad.2008.03.001},
   keywords = {Base excision repair; Aging; DNA damage; Mutagenesis; Health span},
   language = {eng},
   issn = {0047-6374},
   journal = {Mechanisms of ageing and development},
   title = {Base excision repair, aging and health span},
   url = {https://www.sciencedirect.com/science/article/pii/S0047637408000675?via%3Dihub},
   volume = {129},
   year = {2008}
}

TY  - JOUR
ID  - 773202
AU  - Xu, Guogang - Herzig, Maryane - Rotrekl, Vladimír - Walter, Christi, A.
PY  - 2008
TI  - Base excision repair, aging and health span
JF  - Mechanisms of ageing and development
VL  - 129
IS  - 7-8
SP  - 366-382
EP  - 366-382
PB  - Elsevier Science Ireland
SN  - 00476374
KW  - Base excision repair
KW  - Aging
KW  - DNA damage
KW  - Mutagenesis
KW  - Health span
UR  - https://www.sciencedirect.com/science/article/pii/S0047637408000675?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0047637408000675?via%3Dihub
N2  - DNA damage and mutagenesis are suggested to contribute to aging through their ability to mediate cellular dysfunction. The base excision repair (BER) pathway ameliorates a large number of DNA lesions that arise spontaneously. Many of these lesions are reported to increase with age. The specific BER protein that appears to limit activity varies among tissues. DNA polymerase-beta is reduced in brain from aged mice and rats while AP endonuclease is reduced in spermatogenic cells obtained from old mice. The differences in proteins that appear to limit BER activity among tissues may represent true tissue-specific differences in activity or may be due to differences in techniques, environmental conditions or other unidentified differences among the experimental approaches. Much remains to be addressed concerning the potential role of BER in aging and age-related health span.
ER  -

XU, Guogang, Maryane HERZIG, Vladimír ROTREKL and Christi, A. WALTER. Base excision repair, aging and health span. \textit{Mechanisms of ageing and development}. Ireland: Elsevier Science Ireland, 2008, vol.~129, 7-8, p.~366-382. ISSN~0047-6374. Available from: https://dx.doi.org/10.1016/j.mad.2008.03.001.

Detailed Information on Publication Record