Detailed Information on Publication Record
2008
Covalent bonding of azoles to quaternary protoberberine alkaloids
GRYCOVÁ, Lenka, Dagmar HULOVÁ, Lukáš MAIER, Stanislav STANDARA, Marek NEČAS et. al.Basic information
Original name
Covalent bonding of azoles to quaternary protoberberine alkaloids
Name in Czech
Kovalentní vazba azolů na kvartérní protoberberinové alkaloidy
Authors
GRYCOVÁ, Lenka (203 Czech Republic, belonging to the institution), Dagmar HULOVÁ (203 Czech Republic), Lukáš MAIER (203 Czech Republic), Stanislav STANDARA (203 Czech Republic, belonging to the institution), Marek NEČAS (203 Czech Republic, belonging to the institution), Filip LEMIÉRE (56 Belgium), Radovan KAREŠ (203 Czech Republic, belonging to the institution), Jiří DOSTÁL (203 Czech Republic, belonging to the institution) and Radek MAREK (203 Czech Republic, guarantor, belonging to the institution)
Edition
Magnetic Resonance in Chemistry, John Wiley & Sons, 2008, 0749-1581
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10401 Organic chemistry
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.443
RIV identification code
RIV/00216224:14110/08:00024854
Organization unit
Faculty of Medicine
UT WoS
000261163000006
Keywords (in Czech)
NMR; 1H; 13C; 15N; berberin; palmatin; koptisin; protoberberiny; alkaloidy; nukleofilní adice; X-ray difrakce
Keywords in English
NMR; 1H; 13C; 15N; berberine; palmatine; coptisine; protoberberine alkaloid; nucleophilic addition; X-ray diffraction
Tags
Tags
International impact, Reviewed
Změněno: 17/6/2013 14:45, prof. RNDr. Radek Marek, Ph.D.
V originále
Adducts of the quaternary protoberberine alkaloids (QPA) berberine, palmatine, and coptisine were prepared with nucleophiles derived from pyrrole, pyrazole, imidazole, and 1,2,4-triazole. The products, 8-substituted 7,8-dihydroprotoberberines, were identified by mass spectrometry and 1D and 2D NMR spectroscopy, including 1H-15N shift correlations at natural abundance. In addition, two adducts of QPA with chloroform and methanethiolate were characterized by using NMR data. Single-crystal X-ray structures of 8-pyrrolyl-7,8-dihydroberberine, 8-pyrazolyl-7,8-dihydroberberine, and 8-imidazolyl-7,8-dihydroberberine are also presented.
In Czech
Příprava, NMR a RTG studie 8-substituovaných 7,8-dihydroprotoberberinů s kovalentně navázaným pyrrolem, pyrazolem, imidazolem, and 1,2,4-triazolem je popsána a diskutována.
Links
| GA525/04/0017, research and development project |
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| LC06030, research and development project |
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| MSM0021622413, plan (intention) |
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