| BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ, Marie NOVÁKOVÁ and Jiří ŠIMURDA. Perphenazine-Induced block of sodium and transient outward potassium current: experimental and simulation study. Analysis of Biomedical Signals and Images. Brno: Vutium Press, 2008, vol. 19, No 1, p. 1-5. ISSN 1211-412X. |
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@article{776002,
author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Jansová, Dagmar and Šimurdová, Milena and Nováková, Marie and Šimurda, Jiří},
article_location = {Brno},
article_number = {1},
keywords = {sodium current;potassium outward current;simulation},
language = {eng},
issn = {1211-412X},
journal = {Analysis of Biomedical Signals and Images},
title = {Perphenazine-Induced block of sodium and transient outward potassium current: experimental and simulation study},
volume = {19},
year = {2008}
}
TY - JOUR
ID - 776002
AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Jansová, Dagmar - Šimurdová, Milena - Nováková, Marie - Šimurda, Jiří
PY - 2008
TI - Perphenazine-Induced block of sodium and transient outward potassium current: experimental and simulation study
JF - Analysis of Biomedical Signals and Images
VL - 19
IS - 1
SP - 1-5
EP - 1-5
PB - Vutium Press
SN - 1211412X
KW - sodium current;potassium outward current;simulation
N2 - The effect of a neuroleptic drug perphenazine on sodium current INa and transient outward potassium current Ito was studied in rat ventricular myocytes at room temperature. Perphenazine reversibly blocked INa (reducing its amplitude; IC50 = 1.24+/-0.10 micromol/l, nH = 0.99+/-0.08) and Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2+/-3.5 micromol/l, nH = 0.75+/-0.07, evaluated from the changes of time integral). Both INa- and Ito-block was use- and frequency-dependent (20%-increase of INablock and 10%-increase of Ito-block under 0.3 and 10 micromol/l perphenazine, respectively, at the stimulation frequency of 3.3 Hz applied after a 15-s rest). The results of quantitative modelling suggest that perphenazine interacts with INa-channels in inactivated states, and with Ito-channels in both open and open-inactivated states.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ, Marie NOVÁKOVÁ and Jiří ŠIMURDA. Perphenazine-Induced block of sodium and transient outward potassium current: experimental and simulation study. \textit{Analysis of Biomedical Signals and Images}. Brno: Vutium Press, 2008, vol.~19, No~1, p.~1-5. ISSN~1211-412X.
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