Repeated exposure to methamphetamine and methanandamide changes relative expression of D1 receptor in mouse midbrain

LANDA, Leoš and Michal JURAJDA. Repeated exposure to methamphetamine and methanandamide changes relative expression of D1 receptor in mouse midbrain. European Neuropsychopharmacology. Amsterdam: Elsevier, 2008, vol. 18, Suppl. 4, p. S542-S543, 2 pp. ISSN 0924-977X.

Basic information

• Original name: Repeated exposure to methamphetamine and methanandamide changes relative expression of D1 receptor in mouse midbrain
• Name in Czech: Opakovaná expozice metamfetaminu a metanandamidu mění relativní expresi D1 receptorů ve středním mozku myší
• Authors: LANDA, Leoš and Michal JURAJDA.
• Edition: European Neuropsychopharmacology, Amsterdam, Elsevier, 2008, 0924-977X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Spain
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.661
• Organization unit: Faculty of Medicine
• UT WoS: 000259593801381
• Keywords in English: PCR; behavioural sensitization; methamphetamine; cannabinoids; D1 receptor; mesencephalon
• Tags: behavioural sensitization, cannabinoids, D1 receptor, mesencephalon, methamphetamine, PCR
• Tags: International impact, Reviewed

Abstract

The results of the behavioural investigation showed: a) significant stimulatory influence of methamphetamine after the acute administration, b) development of sensitization to methamphetamine after its repeated treatment, c) development of cross-sensitization to methamphetamine after repeated pre-treatment with CB1 receptor agonist methanandamide. Real-time PCR results showed increased D1 mRNA expression both in animals sensitized to methamphetamine and in animals cross-sensitized to methamphetamine (repeatedly pre-treated with methanandamide).

Abstract (in Czech)

Výsledky behaviorální části experimentu ukázaly: a) signifikantní stimulační vliv metamfetaminu po akutním podání, b) rozvoj senzitizace k metamfetaminu po opakovaném podávání, c) rozvoj zkřížené senzitizace k metamfetaminu po opakované předcházející aplikaci agonisty CB1 receptorů metanandamidu. Výsledky real-time PCR ukázaly zvýšenou expresi D1 mRNA jak u zvířat senzitizovaných k metamfetaminu, tak u zvířat se zkříženou senzitizací k metamfetaminu (po opakované předchozí aplikaci metanandamidu).

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.