Detailed Information on Publication Record
2009
The association of MMP-9 and IL-18 gene promoter polymorphisms with gingivitis in adolescent
VOKURKA, Jan, Lucie KLAPUŠOVÁ, Pavla PANTUCKOVA, Martina KUKLETOVÁ, Lubomír KUKLA et. al.Basic information
Original name
The association of MMP-9 and IL-18 gene promoter polymorphisms with gingivitis in adolescent
Name in Czech
Asociace promotorových polymorfizmů v genech pro MMP-9 a IL-18 s gingivitidou u adolescentů
Authors
VOKURKA, Jan (203 Czech Republic), Lucie KLAPUŠOVÁ (203 Czech Republic), Pavla PANTUCKOVA (203 Czech Republic), Martina KUKLETOVÁ (203 Czech Republic), Lubomír KUKLA (203 Czech Republic) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor)
Edition
Arch Oral Biol, Amsterodam, Elsevier, 2009, 0003-9969
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.649
RIV identification code
RIV/00216224:14110/09:00033798
Organization unit
Faculty of Medicine
UT WoS
000263189600010
Keywords in English
gingivitis; gene; polymorphism; IL-18; MMP; interleukin
Tags
Tags
International impact, Reviewed
Změněno: 17/6/2009 11:09, prof. MUDr. Lydie Izakovičová Hollá, Ph.D.
V originále
Interleukin 18 (IL-18) is shown to be a proinflammatory cytokine that regulates the expression of matrix metalloproteinase 9 (MMP-9). The aim of this study was to test for differences between Czech adolescents with and without gingivitis in relation to MMP-9 and IL-18 polymorphisms. The -1562 T allele of MMP-9 gene could have a role in gingivitis in adolescents. In addition, interaction of the MMP-9 and IL-18 genes could be considered a risk factor for the development of gingivitis in children.
In Czech
Interleukin 18 (IL-18) je prozánětlivým cytokinem, který reguluje expresi matrix metaloproteinázy 9 (MMP-9). Cílem naší práce bylo analyzovat rozdíly ve frekvencích MMP-9 a IL-18 variant mezi českými dětmi se zdravou gingivou a gingivitidou. T alela polymorfizmu -1562 v genu pro MMP-9 může hrát roli při rozvoji gingivitidy u adolescentů. Navíc, interakce MMP-9a IL-18 genových variant může být považována za rizikový faktor vývoje gingivitidy u dětí.
Links
| NR9129, research and development project |
| ||
| 1M0528, research and development project |
|