Detailed Information on Publication Record
2008
Synthesis and structure_activity relationship studies of theophylline analogs
ANANTHALAKSHMI, Kethireddy V. V., Tomáš BARTL, Mohammed H. AZIZA, Ladislav NOVOTNÝ, Radek MAREK et. al.Basic information
Original name
Synthesis and structure_activity relationship studies of theophylline analogs
Name in Czech
Synthesis and structure_activity relationship studies of theophylline analogs
Authors
ANANTHALAKSHMI, Kethireddy V. V. (414 Kuwait), Tomáš BARTL (203 Czech Republic, guarantor), Mohammed H. AZIZA (414 Kuwait), Ladislav NOVOTNÝ (414 Kuwait), Radek MAREK (203 Czech Republic), Luděk BENEŠ (203 Czech Republic) and Samuel B. KOMBIAN (414 Kuwait)
Edition
Bioorganic & Medicinal Chemistry, Elsevier, 2008, 0968-0896
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10600 1.6 Biological sciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.075
RIV identification code
RIV/00216224:14310/08:00026369
Organization unit
Faculty of Science
UT WoS
000258827800032
Keywords in English
Hippocampus; Acetylcholine receptors; Dementia; Nootropic; Theophylline analogs
Tags
International impact, Reviewed
Změněno: 25/6/2009 11:33, prof. RNDr. Radek Marek, Ph.D.
V originále
We synthesized several theophylline analogs and tested the hypothesis that these compounds may be nootropic or cognitive enhancers by examining their effects on evoked population spikes recorded extracellularly in the CA1 region of the rat hippocampus. Whereas the length of the carbon chain on N7 had no effect, different size of the terminal lactam ring strongly influenced neuroactivity. Our results suggest that hexahydroazepin-2-one analogs have potential for further development as cognitive enhancers.
In Czech
Byly syntetizovány nové deriváty theofylinu a testována jejich potenciální nootropní aktivita.
Links
| LC06030, research and development project |
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| MSM0021622413, plan (intention) |
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