Phenotype determination of CYP2D6 in psychiatric patients -
possibilities and implications

J 2008

Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications

JUŘICA, Jan, Alexandra ŽOURKOVÁ, Eva FLODROVÁ and Eva MCCASKEY HADAŠOVÁ

Basic information

Original name

Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications

Name in Czech

Stanovení fenotypu CYP2D6 u psychiatrických pacientů - možnosti a souvslosti.

Authors

JUŘICA, Jan, Alexandra ŽOURKOVÁ, Eva FLODROVÁ and Eva MCCASKEY HADAŠOVÁ

Edition

Prague medical report : interdisciplinary biomedical journal of the First Faculty of Medicine, Charles University in Prague. Prague, Karolinum, 2008, 1214-6994

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords in English

CYP2D6; phenotype; psychiatry

Abstract

ORIG CZ

V originále

Possibilities of CYP2D6 phenotype and genotype determination in psychiatric patients were discussed. Then, the the influence of phenotype of CYP2D6 on clinical response was evaluated (patients with anxiety disorder on paroxetine treatment; n=16). Influence of phenotype on the adverse effects occurence was evaluated as well (including sexual dysfunctions) in the long term paroxetine treatment(patients treated with paroxetine for more than 3 months; n=50).

In Czech

Přehled možností, výhod a nevýhod stanovení genotypu a fenotypu CYP2D6 u psychiatrických pacientů. Dále jsou uvedeny výsledky zkoumání souvislosti fenotypu CYP2D6 a klinické odpovědi na terapii paroxetinem u anxiozních pacientů a souvisloti fenotypu CYP2D6 a výskytu nežádoucích účinků léčby při dlouhodobé terapii paroxetinem.

Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

JUŘICA, Jan, Alexandra ŽOURKOVÁ, Eva FLODROVÁ and Eva MCCASKEY HADAŠOVÁ. Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications (Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications.). Prague medical report : interdisciplinary biomedical journal of the First Faculty of Medicine, Charles University in Prague. Prague: Karolinum, 2008, vol. 2008, No 109, p. 54-56. ISSN 1214-6994.

@article{777274,
   author = {Juřica, Jan and Žourková, Alexandra and Flodrová, Eva and McCaskey Hadašová, Eva},
   article_location = {Prague},
   article_number = {109},
   keywords = {CYP2D6; phenotype; psychiatry},
   language = {eng},
   issn = {1214-6994},
   journal = {Prague medical report : interdisciplinary biomedical journal of the First Faculty of Medicine, Charles University in Prague.},
   title = {Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications},
   volume = {2008},
   year = {2008}
}

TY  - JOUR
ID  - 777274
AU  - Juřica, Jan - Žourková, Alexandra - Flodrová, Eva - McCaskey Hadašová, Eva
PY  - 2008
TI  - Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications
JF  - Prague medical report : interdisciplinary biomedical journal of the First Faculty of Medicine, Charles University in Prague.
VL  - 2008
IS  - 109
SP  - 54-56
EP  - 54-56
PB  - Karolinum
SN  - 12146994
KW  - CYP2D6
KW  - phenotype
KW  - psychiatry
N2  - Possibilities of CYP2D6 phenotype and genotype determination in psychiatric patients were discussed. Then, the the influence of phenotype of CYP2D6 on clinical response was evaluated (patients with anxiety disorder on paroxetine treatment; n=16). Influence of phenotype on the adverse effects occurence was evaluated as well (including sexual dysfunctions) in the long term paroxetine treatment(patients treated with paroxetine for more than 3 months; n=50).
ER  -

JUŘICA, Jan, Alexandra ŽOURKOVÁ, Eva FLODROVÁ and Eva MCCASKEY HADAŠOVÁ. Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications (Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications.). \textit{Prague medical report : interdisciplinary biomedical journal of the First Faculty of Medicine, Charles University in Prague.}. Prague: Karolinum, 2008, vol.~2008, No~109, p.~54-56. ISSN~1214-6994.

Detailed Information on Publication Record