Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications

JUŘICA, Jan, Alexandra ŽOURKOVÁ, Eva FLODROVÁ and Eva MCCASKEY HADAŠOVÁ. Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications (Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications.). Prague medical report : interdisciplinary biomedical journal of the First Faculty of Medicine, Charles University in Prague. Prague: Karolinum, 2008, vol. 2008, No 109, p. 54-56. ISSN 1214-6994.

Basic information

• Original name: Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications
• Name in Czech: Stanovení fenotypu CYP2D6 u psychiatrických pacientů - možnosti a souvslosti.
• Authors: JUŘICA, Jan, Alexandra ŽOURKOVÁ, Eva FLODROVÁ and Eva MCCASKEY HADAŠOVÁ.
• Edition: Prague medical report : interdisciplinary biomedical journal of the First Faculty of Medicine, Charles University in Prague. Prague, Karolinum, 2008, 1214-6994.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• Keywords in English: CYP2D6; phenotype; psychiatry
• Tags: CYP2D6, phenotype, psychiatry
• Tags: International impact

Abstract

Possibilities of CYP2D6 phenotype and genotype determination in psychiatric patients were discussed. Then, the the influence of phenotype of CYP2D6 on clinical response was evaluated (patients with anxiety disorder on paroxetine treatment; n=16). Influence of phenotype on the adverse effects occurence was evaluated as well (including sexual dysfunctions) in the long term paroxetine treatment(patients treated with paroxetine for more than 3 months; n=50).

Abstract (in Czech)

Přehled možností, výhod a nevýhod stanovení genotypu a fenotypu CYP2D6 u psychiatrických pacientů. Dále jsou uvedeny výsledky zkoumání souvislosti fenotypu CYP2D6 a klinické odpovědi na terapii paroxetinem u anxiozních pacientů a souvisloti fenotypu CYP2D6 a výskytu nežádoucích účinků léčby při dlouhodobé terapii paroxetinem.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.