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@article{777995,
author = {Vašků, Anna and Vokurka, Jiří and Bienertová Vašků, Julie},
article_location = {Heidelberg, Německo},
article_number = {xx},
keywords = {obesity-related genes; colorectal cancer; leptin; leptin receptor},
language = {eng},
issn = {0179-1958},
journal = {International Journal of Colorectal Disease},
title = {Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results.},
volume = {15/2008},
year = {2008}
}
TY - JOUR
ID - 777995
AU - Vašků, Anna - Vokurka, Jiří - Bienertová Vašků, Julie
PY - 2008
TI - Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results.
JF - International Journal of Colorectal Disease
VL - 15/2008
IS - xx
SP - xx
EP - xx
PB - Springer Verlag
SN - 01791958
KW - obesity-related genes
KW - colorectal cancer
KW - leptin
KW - leptin receptor
N2 - BACKGROUND: Genetic variability in obesity-related genes and the resulting phenotypes are being recognized as major risk factors for colorectal cancer and/or severity of the disease. MATERIALS AND METHODS: A total of 102 patients (aged 68 +/- 10.2 years, 79 men and 23 women) and 101 age-matched (68.1 +/- 5.4 years old) individuals without colorectal cancer, 59 men and 42 women, were recruited. All the individuals were genotyped for the following subset of polymorphisms in obesity-related genes: angiotensinogen gene (M235T and -6A/G), in IL-6 gene (-174 G/C and -596 A/G), in leptin gene (-2548 A/G), and polymorphism Gln223Arg within the leptin receptor (LEPR) gene. RESULTS: A significant increase in frequency of double heterozygote genotype (MTAG) of both angiotensinogen polymorphisms in males with colorectal cancer was observed when compared to control men [odds ratio (OR) = 3.77, P (corr) = 0.001]. A marginally significant difference in genotype distribution of -174 G/C IL-6 polymorphism between the patients in stage I-II compared to patients in III-IV was found (P (g) = 0.05, P (a) = 0.173). The GG genotype of -174 G/C IL-6 polymorphism in the patients in stage III-IV carries an increased risk compared to those in stage I-II (OR = 2.83, P (corr) = 0.06). Similarly, a difference in genotype distribution of Gln223Arg in LEPR gene between the patients staged I-II compared to III-IV was observed (P (g) = 0.05). The AA genotype was shown to be risky for the patients staged III-IV (OR = 3.35, P (corr) = 0.06). CONCLUSIONS: The investigated single nucleotide polymorphisms within the genes encoding for obesity-related genes were observed to be associated both with clinical manifestation of colorectal cancer and with severity of the disease. Thus, we suggest that defined genetic variability in the genes might become DNA markers for colorectal cancer in the future.
ER -
VAŠKŮ, Anna, Jiří VOKURKA a Julie BIENERTOVÁ VAŠKŮ. Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. \textit{International Journal of Colorectal Disease}. Heidelberg, Německo: Springer Verlag, roč.~15/2008, xx, s.~xx, 7 s. ISSN~0179-1958. 2008.
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