TOMANDL, Josef, Richard SALZMAN, Eva TOTHOVA, Lukáš PÁCAL, Kateřina KAŇKOVÁ and Rom KOSTŘICA. Malondialdehyde as a prognostic parameter in squamous cell carcinoma of oral cavity and oropharynx. In Sborník přednášek. 1st ed. Praha: Česká společnost pro biochemii a molekulární biologii, 2008, p. 126-126. ISBN 80-86313-21-2.
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Basic information
Original name Malondialdehyde as a prognostic parameter in squamous cell carcinoma of oral cavity and oropharynx
Name in Czech Malondialdehyd jako prognostický parametr u karcinomu dutiny ústní a hltanu
Authors TOMANDL, Josef, Richard SALZMAN, Eva TOTHOVA, Lukáš PÁCAL, Kateřina KAŇKOVÁ and Rom KOSTŘICA.
Edition 1. vyd. Praha, Sborník přednášek, p. 126-126, 1 pp. 2008.
Publisher Česká společnost pro biochemii a molekulární biologii
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10600 1.6 Biological sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW XXI. biochemický sjezd
Organization unit Faculty of Medicine
ISBN 80-86313-21-2
Keywords in English malondialdehyde; marker; head and neck squamous cell carcinoma
Tags malondialdehyde, marker
Tags International impact
Changed by Changed by: MUDr. Eva Tóthová, učo 152420. Changed: 21/1/2009 08:10.
Abstract
Oxidative stress and chronic inflammation certainly plays a significant role in head and neck carcinogenesis. Increased production of reactive oxygen species and metabolites such as malondialdehyde (MDA) a product of lipid peroxidation and cyclooxygenase activity may in turn induce DNA damage and mutations and, as a result, be carcinogenic. The aim of the study was to investigate relationships between MDA and the oncologic characteristics and survival parameters of patients with head and neck squamous cell carcinoma (HNSCC). We found significantly different level of MDA in T1-2 and T3-4 patients (p < 0.001) and strong correlation between MDA and T-stages (p < 0.0001). Besides, the level of MDA was significantly elevated in patients who manifested disease relapse during 3 years following the surgical tumor removal (p < 0.01). Our results confirm that advanced disease stages and recurrences in patients with HNSCC are accompanied by an increased oxidative stress.
Abstract (in Czech)
Oxidative stress and chronic inflammation certainly plays a significant role in head and neck carcinogenesis. Increased production of reactive oxygen species and metabolites such as malondialdehyde (MDA) a product of lipid peroxidation and cyclooxygenase activity may in turn induce DNA damage and mutations and, as a result, be carcinogenic. The aim of the study was to investigate relationships between MDA and the oncologic characteristics and survival parameters of patients with head and neck squamous cell carcinoma (HNSCC). We found significantly different level of MDA in T1-2 and T3-4 patients (p < 0.001) and strong correlation between MDA and T-stages (p < 0.0001). Besides, the level of MDA was significantly elevated in patients who manifested disease relapse during 3 years following the surgical tumor removal (p < 0.01). Our results confirm that advanced disease stages and recurrences in patients with HNSCC are accompanied by an increased oxidative stress.
Links
NR9200, research and development projectName: Dynamika oxidativního stresu během onkoterapie ve vztahu k prognóze u pacientů s karcinomy hlavy a krku
Investor: Ministry of Health of the CR
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