Fertility in male patients with newly diagnosed Hodgkin´s
lymphoma

a 2008

Fertility in male patients with newly diagnosed Hodgkin´s lymphoma

ŠMARDOVÁ, Lenka, Zdeněk KRÁL, Igor CRHA, Ingrid VÁŠOVÁ, Jiří VORLÍČEK et. al.

Basic information

Original name

Fertility in male patients with newly diagnosed Hodgkin´s lymphoma

Name in Czech

Fertilita u pacientů s nově diagnostikovaným Hodgkinským lymfomem

Authors

ŠMARDOVÁ, Lenka, Zdeněk KRÁL, Igor CRHA, Ingrid VÁŠOVÁ and Jiří VORLÍČEK

Edition

Praha, Česká Republika, European Andrology (suplementum), p. 44-44, 1 pp. 2008

Publisher

Androgeos

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

ISSN

Keywords in English

Hodgkin lymphoma; fertility

Abstract

ORIG CZ

V originále

Introduction: The prognosis of pts with Hodgkins lymphoma (HL) has improved over the last decades. Depending on stage of disease, more than 80% of pts can be cured, but they are at higher risk for secondary malignancies and other late effects such as infertility. Even if the most HL pts are young, several studies have shown they have inadequate sperm quality even before cytostatic treatment. Material and methods: We evaluated semen and hormonal analysis in newly diagnosed pts with HL to demonstrate the fertility status at the time of diagnosis. We examined a total of 80 male pts, with median age 26 yrs (16-42). Most pts were in early clinical stage (33 pts; 41%), followed by the group of pts in advanced st. (28 pts; 35%) and in intermediate st. (19 pts; 24%). The semen samples parameters were compared with a reference set of 89 healthy men interested in sperm donation, with median age of 23 yrs (18-35). The t-test was used for statistical evaluations. Results: In 95% (N=76) of the pts, inadequate semen quality was established, with low sperm cell count and/or defective sperm morphology. Severe defects such as azoospermia and OAT were found in 14% (n=11) and 26% (n=21) pts respectively. In other pts, combined damages such as asthenospermia in 14% (n=11) and asthenoteratospermia in 41% (n=33) were identified. Normal findings were only established in 4 pts. In comparison with the control set of healthy men, statistically significant differences were found (p=0,05) in the average concentration (31,6 vs 55,7 mil/ml) and in the presence of progressively motile sperm cells (14,2% vs 43,6%). No deviation from the normal reference range of serum levels of FSH, LH and testosterone could be established in anyone of the pts. Conclusions: The majority of pts in our study had inadequate semen quality before treatment. The underlying mechanism is still unknown. Suspected factors include damage in the germinal epithelium, disturbance in the hypothalamic-hypophysial axis and the impact of the disease-related cytokines on spermatogenesis.

In Czech

Fertilita u pacientů s nově diagnostikovaným Hodgkinským lymfomem.

Citovat

ŠMARDOVÁ, Lenka, Zdeněk KRÁL, Igor CRHA, Ingrid VÁŠOVÁ and Jiří VORLÍČEK. Fertility in male patients with newly diagnosed Hodgkin´s lymphoma. In European Andrology (suplementum). Praha, Česká Republika: Androgeos, 2008, p. 44-44. ISSN 1802-4793.

@proceedings{778614,
   author = {Šmardová, Lenka and Král, Zdeněk and Crha, Igor and Vášová, Ingrid and Vorlíček, Jiří},
   address = {Praha, Česká Republika},
   booktitle = {European Andrology (suplementum)},
   keywords = {Hodgkin lymphoma; fertility},
   language = {eng},
   location = {Praha, Česká Republika},
   pages = {44-44},
   publisher = {Androgeos},
   title = {Fertility in male patients with newly diagnosed Hodgkin´s lymphoma},
   year = {2008}
}

TY  - CONF
ID  - 778614
AU  - Šmardová, Lenka - Král, Zdeněk - Crha, Igor - Vášová, Ingrid - Vorlíček, Jiří
PY  - 2008
TI  - Fertility in male patients with newly diagnosed Hodgkin´s lymphoma
PB  - Androgeos
CY  - Praha, Česká Republika
KW  - Hodgkin lymphoma
KW  - fertility
N2  - Introduction: The prognosis of pts with Hodgkins lymphoma (HL) has improved over the last decades. Depending on stage of disease, more than 80% of pts can be cured, but they are at higher risk for secondary malignancies and other late effects such as infertility. Even if the most HL pts are young, several studies have shown they have inadequate sperm quality even before cytostatic treatment. Material and methods: We evaluated semen and hormonal analysis in newly diagnosed pts with HL to demonstrate the fertility status at the time of diagnosis. We examined a total of 80 male pts, with median age 26 yrs (16-42). Most pts were in early clinical stage (33 pts; 41%), followed by the group of pts in advanced st. (28 pts; 35%) and in intermediate st. (19 pts; 24%). The semen samples parameters were compared with a reference set of 89 healthy men interested in sperm donation, with median age of 23 yrs (18-35). The t-test was used for statistical evaluations. Results: In 95% (N=76) of the pts, inadequate semen quality was established, with low sperm cell count and/or defective sperm morphology. Severe defects such as azoospermia and OAT were found in 14% (n=11) and 26% (n=21) pts respectively. In other pts, combined damages such as asthenospermia in 14% (n=11) and asthenoteratospermia in 41% (n=33) were identified. Normal findings were only established in 4 pts. In comparison with the control set of healthy men, statistically significant differences were found (p=0,05) in the average concentration (31,6 vs 55,7 mil/ml) and in the presence of progressively motile sperm cells (14,2% vs 43,6%). No deviation from the normal reference range of serum levels of FSH, LH and testosterone could be established in anyone of the pts. Conclusions: The majority of pts in our study had inadequate semen quality before treatment. The underlying mechanism is still unknown. Suspected factors include damage in the germinal epithelium, disturbance in the hypothalamic-hypophysial axis and the impact of the disease-related cytokines on spermatogenesis.
ER  -

ŠMARDOVÁ, Lenka, Zdeněk KRÁL, Igor CRHA, Ingrid VÁŠOVÁ and Jiří VORLÍČEK. Fertility in male patients with newly diagnosed Hodgkin´s lymphoma. In \textit{European Andrology (suplementum)}. Praha, Česká Republika: Androgeos, 2008, p.~44-44. ISSN~1802-4793.

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