Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature.

BRÁZDA, Václav, Ilona KLUSÁKOVÁ, Ivana SVÍŽENSKÁ, Zuzana VESELKOVÁ, Radim JANČÁLEK and Petr DUBOVÝ. Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature. In 6th International Symposium on Experimental and Clinical Neurobiology. 2008. ISBN 978-80-7399-489-1.

Basic information

• Original name: Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature.
• Name in Czech: Změny IL-6 a jeho receptoru ve spinálních gangliích potkana po ligatuře spinálního nervu.
• Authors: BRÁZDA, Václav, Ilona KLUSÁKOVÁ, Ivana SVÍŽENSKÁ, Zuzana VESELKOVÁ, Radim JANČÁLEK and Petr DUBOVÝ.
• Edition: 6th International Symposium on Experimental and Clinical Neurobiology, 2008.

Other information

• Original language: English
• Type of outcome: Presentations at conferences
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• ISBN: 978-80-7399-489-1
• Keywords in English: neuropathic pain, sciatic nerve ligature, IL-6 protein, gp130

Abstract

Robust axon regeneration and neuropathic pain induction occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. The sciatic nerve injury induces up-regulation of IL-6. We were used ligature of spinal nerves for investigation of temporal changes of IL-6 protein and its receptor gp130 in both ipsi- and contralateral lumbal (L4-L5) dorsal root ganglia. The obtained data provide evidence for changes of IL-6 protein levels not only in dorsal root ganglia's associated with damaged nerve, but also in those non-associated with nerve injury in the rat experimental neuropathic pain model.

Links

• GA309/07/0121, research and development project: Name: Změny cytokinů ve spinálních gangliích experimentálních modelů neuropatické bolesti indukované unilaterálním poškozením nervu

Investor: Czech Science Foundation, Spatio-temporal changes of cytokines in the dorsal root ganglia of experimental neuropathic pain models induced by unilateral nerve injury

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.