| ONDROUŠKOVÁ, Eva, Jana SLOVÁČKOVÁ, Vendula PELKOVÁ, Jiřina PROCHÁZKOVÁ, Karel SOUČEK, Petr BENEŠ and Jan ŠMARDA. Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase. Biological Chemistry. Berlin, DE: Walter de Gruyter&CO, 2009, 390/2009, No 12, p. 49-58, 9 pp. ISSN 1431-6730. |
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@article{780737,
author = {Ondroušková, Eva and Slováčková, Jana and Pelková, Vendula and Procházková, Jiřina and Souček, Karel and Beneš, Petr and Šmarda, Jan},
article_location = {Berlin, DE},
article_number = {12},
keywords = {Bcl-2; heavy metals; Jun N-terminal kinase; phosphorylation; posttranslational modification},
language = {eng},
issn = {1431-6730},
journal = {Biological Chemistry},
title = {Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase},
volume = {390/2009},
year = {2009}
}
TY - JOUR
ID - 780737
AU - Ondroušková, Eva - Slováčková, Jana - Pelková, Vendula - Procházková, Jiřina - Souček, Karel - Beneš, Petr - Šmarda, Jan
PY - 2009
TI - Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase
JF - Biological Chemistry
VL - 390/2009
IS - 12
SP - 49-58
EP - 49-58
PB - Walter de Gruyter&CO
SN - 14316730
KW - Bcl-2
KW - heavy metals
KW - Jun N-terminal kinase
KW - phosphorylation
KW - posttranslational modification
N2 - The Bcl-2 protein is one of the key components of biochemical pathways controling programmed cell death. Function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significantly associated with cell cycle arrest in the G2/M phase of the cell cycle, and with cell death caused by defects of microtubule dynamics. This study shows that phosphorylation of Bcl-2 can be induced by heavy metals due to activation of the Jun N-terminal kinase pathway that is not linked to the G2/M cell cycle arrest. Furthermore, we show that hyperphosphorylated Bcl-2 protein is a more potent inhibitor of zinc-induced cell death than its hypophosphorylated mutant form. These data suggest that regulation of the Bcl-2 protein function by phosphorylation is an important part of cell response to stress.
ER -
ONDROUŠKOVÁ, Eva, Jana SLOVÁČKOVÁ, Vendula PELKOVÁ, Jiřina PROCHÁZKOVÁ, Karel SOUČEK, Petr BENEŠ and Jan ŠMARDA. Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase. \textit{Biological Chemistry}. Berlin, DE: Walter de Gruyter\&{}CO, 2009, 390/2009, No~12, p.~49-58, 9 pp. ISSN~1431-6730.
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