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@article{786416,
author = {Drtílková, Ivana and Šerý, Omar and Theiner, Pavel and Uhrová, Alena and Žáčková, Markéta and Balaštíková, Blanka and Znojil, Vladimír},
article_location = {Sweden, Stockholm},
article_number = {3},
keywords = {molecular genetic study; ADHD; DRD2; DAT1; AGT; IL-6; TNF-alpha; BDNF},
language = {eng},
issn = {0172-780X},
journal = {Neuroendocrinology Letters},
title = {Clinical and molecular-genetic markers of ADHD in children},
volume = {29},
year = {2008}
}
TY - JOUR
ID - 786416
AU - Drtílková, Ivana - Šerý, Omar - Theiner, Pavel - Uhrová, Alena - Žáčková, Markéta - Balaštíková, Blanka - Znojil, Vladimír
PY - 2008
TI - Clinical and molecular-genetic markers of ADHD in children
JF - Neuroendocrinology Letters
VL - 29
IS - 3
SP - 320-327
EP - 320-327
PB - Maghira and Maas Publications
SN - 0172780X
KW - molecular genetic study
KW - ADHD
KW - DRD2
KW - DAT1
KW - AGT
KW - IL-6
KW - TNF-alpha
KW - BDNF
N2 - OBJECTIVES: The objective was to make a contribution to deepening the knowledge of the etiopathogenesis of ADHD. DESIGN: in an association study design, an analysis of polymorphisms of selected genes was conducted in 119 hyperkinetic boys and a control group of boys, aged 7 to 13. Furthermore several psychologically determined subgroups were identified. A connection between psychological functions (endophenotypes) and genes were looked for. RESULTS: There was a statistically significant difference found in allelic and genotype frequencies of the TaqI A polymorphism of the DRD2 gene. The frequency of the allele A1 in hyperkinetic boys and the control subjects was 0.26 and 0.15, respectively (0.003). A statistically significant occurrence of atypical genotypes (8/10, 7/10 and 10/11) of the DAT1 gene was also found in hyperkinetic boys and a connection between the M235 polymorphi sm of the angiotensinogene gene and the positive family history of psychiatric illness was found in probands (p=0.031). Significant correlations between the results of some neuropsychological tests and genes for neuro-/immunomodulators (IL-6, TNF-alpha) and the gene for the brain-derived neurotrophic factor (BDNF) were found. CONCLUSION: The study showed a statistically significant prevalence of A1 allele of the DRD gene in the hyperkinetic group. We also found a significantly higher incidence of atypical DAT genotypes in the hyperkinetic group. Furthermore we found significant connections with particular gene polymorphisms which may hypothetically represent a neurodevelopmental risk factor in the etiopathogenesis of the disorder (IL-2, IL-6, TNF-alpha, BDNF). We further found a connection of the M235 polymorphism of the AGT (angiotensinogene) gene to positive family history of psychiatric illness (p=0.031). As for cognitive characteristics, we identified three subtypes with different cognitive performance profiles. This finding shows interindividual variability of cognitive style in the group of hyperkinetic boys.
ER -
DRTÍLKOVÁ, Ivana, Omar ŠERÝ, Pavel THEINER, Alena UHROVÁ, Markéta ŽÁČKOVÁ, Blanka BALAŠTÍKOVÁ a Vladimír ZNOJIL. Clinical and molecular-genetic markers of ADHD in children. \textit{Neuroendocrinology Letters}. Sweden, Stockholm: Maghira and Maas Publications, roč.~29, č.~3, s.~320-327. ISSN~0172-780X. 2008.
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