DRTÍLKOVÁ, Ivana, Omar ŠERÝ, Pavel THEINER, Alena UHROVÁ, Markéta ŽÁČKOVÁ, Blanka BALAŠTÍKOVÁ and Vladimír ZNOJIL. Clinical and molecular-genetic markers of ADHD in children. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, 2008, vol. 29, No 3, p. 320-327. ISSN 0172-780X.
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Basic information
Original name Clinical and molecular-genetic markers of ADHD in children
Name in Czech Klinické a molekulárně-genetické markery ADHD u dětí
Authors DRTÍLKOVÁ, Ivana (203 Czech Republic), Omar ŠERÝ (203 Czech Republic, guarantor), Pavel THEINER (203 Czech Republic), Alena UHROVÁ (203 Czech Republic), Markéta ŽÁČKOVÁ (203 Czech Republic), Blanka BALAŠTÍKOVÁ (203 Czech Republic) and Vladimír ZNOJIL (203 Czech Republic).
Edition Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2008, 0172-780X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Sweden
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.359
RIV identification code RIV/00216224:14310/08:00028246
Organization unit Faculty of Science
UT WoS 000257677800007
Keywords in English molecular genetic study; ADHD; DRD2; DAT1; AGT; IL-6; TNF-alpha; BDNF
Tags ADHD, AGT, BDNF, DAT1, DRD2, IL-6, molecular genetic study, TNF-alpha
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Omar Šerý, Ph.D., učo 18120. Changed: 22/10/2008 16:55.
OBJECTIVES: The objective was to make a contribution to deepening the knowledge of the etiopathogenesis of ADHD. DESIGN: in an association study design, an analysis of polymorphisms of selected genes was conducted in 119 hyperkinetic boys and a control group of boys, aged 7 to 13. Furthermore several psychologically determined subgroups were identified. A connection between psychological functions (endophenotypes) and genes were looked for. RESULTS: There was a statistically significant difference found in allelic and genotype frequencies of the TaqI A polymorphism of the DRD2 gene. The frequency of the allele A1 in hyperkinetic boys and the control subjects was 0.26 and 0.15, respectively (0.003). A statistically significant occurrence of atypical genotypes (8/10, 7/10 and 10/11) of the DAT1 gene was also found in hyperkinetic boys and a connection between the M235 polymorphi sm of the angiotensinogene gene and the positive family history of psychiatric illness was found in probands (p=0.031). Significant correlations between the results of some neuropsychological tests and genes for neuro-/immunomodulators (IL-6, TNF-alpha) and the gene for the brain-derived neurotrophic factor (BDNF) were found. CONCLUSION: The study showed a statistically significant prevalence of A1 allele of the DRD gene in the hyperkinetic group. We also found a significantly higher incidence of atypical DAT genotypes in the hyperkinetic group. Furthermore we found significant connections with particular gene polymorphisms which may hypothetically represent a neurodevelopmental risk factor in the etiopathogenesis of the disorder (IL-2, IL-6, TNF-alpha, BDNF). We further found a connection of the M235 polymorphism of the AGT (angiotensinogene) gene to positive family history of psychiatric illness (p=0.031). As for cognitive characteristics, we identified three subtypes with different cognitive performance profiles. This finding shows interindividual variability of cognitive style in the group of hyperkinetic boys.
Abstract (in Czech)
V rámci asociační studie byla provedena analýza polymorfizmů kandidátních genů u 119 chlapců s diagnózou hyperkinetické poruchy ve věku 7-13 let a kontrolní skupiny 153 chlapců. Statisticky významný rozdíl v alelických a genotypových frekvencích byl objeven u TaqI A polymorfizmu genu pro DRD2. Frekvence alely A1 byla u hyperkinetických dětí 0,26, u kontrolního souboru 0,15 (p<0,003). U chlapců s hyperkinetickou poruchou byl dále zjištěn statisticky významný výskyt atypických genotypů (8/10, 7/10 a 10/11) polymorfizmu genu pro DAT1a byla nalezena souvislost s polymorfizmem M235 genu pro AGT (angiotensinogen) a výskytem psychiatrické heredity v rodinách probandů (p=0,031). Zjistili jsme signifikantní korelaci mezi výsledky v některých neuropsychologických testech a polymorfizmy genů pro cytokiny (IL-6 a TNF alfa) a polymorfizmem genu pro neuronální růstový faktor BDNF.
NR9298, research and development projectName: Rizikové faktory u perzistentní formy hyperkinetické poruchy(ADHD).Longitudinální,klinická a molekulárně-genetická studie.
Investor: Ministry of Health of the CR
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