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@inproceedings{788656, author = {Ondroušková, Eva and Slováčková, Jana and Pelková, Vendula and Procházková, Jiřina and Souček, Karel and Beneš, Petr and Šmarda, Jan}, address = {Brno}, booktitle = {XIX. Biologické dny. Biologický výzkum pro lidské zdraví}, keywords = {Bcl-2; heavy metals; Jun N-terminal kinase; phosphorylation; posttranslational modification}, language = {eng}, location = {Brno}, isbn = {978-80-7399-545-4}, pages = {74-75}, publisher = {Československá biologická společnost a LF Univerzity Karlovy v Hradci Králové}, title = {Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase}, year = {2008} }
TY - JOUR ID - 788656 AU - Ondroušková, Eva - Slováčková, Jana - Pelková, Vendula - Procházková, Jiřina - Souček, Karel - Beneš, Petr - Šmarda, Jan PY - 2008 TI - Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase PB - Československá biologická společnost a LF Univerzity Karlovy v Hradci Králové CY - Brno SN - 9788073995454 KW - Bcl-2 KW - heavy metals KW - Jun N-terminal kinase KW - phosphorylation KW - posttranslational modification N2 - The Bcl-2 protein is one of the key components of biochemical pathways controling programmed cell death. Function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significantly associated with cell cycle arrest in the G2/M phase of the cell cycle, and with cell death caused by defects of microtubule dynamics. In this study, we show that heavy metal-induced stress and cell death correlate with induction of the Bcl-2 protein phosphorylation in several cell lines. Zinc-induced phosphorylation of Bcl-2 is mediated by the Jun N-terminal kinase pathway, and it is not linked to cell cycle arrest at G2/M. Cells of breast carcinoma cell line MDA-MB-231 expressing the wild-type Bcl-2 protein are more resistant to zinc-induced cell death than those expressing mutant variant of Bcl-2 that cannot be phosphorylated at amino acid residues Ser70, Ser87, Thr69. These results suggest that phosphorylation of the Bcl-2 protein is an important part of cellular response to the stress and that this posttranslational modification is significantly involved in control of the Bcl-2 protein function. ER -
ONDROUŠKOVÁ, Eva, Jana SLOVÁČKOVÁ, Vendula PELKOVÁ, Jiřina PROCHÁZKOVÁ, Karel SOUČEK, Petr BENEŠ and Jan ŠMARDA. Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase. In \textit{XIX. Biologické dny. Biologický výzkum pro lidské zdraví}. Brno: Československá biologická společnost a LF Univerzity Karlovy v Hradci Králové, 2008, p.~74-75. ISBN~978-80-7399-545-4.
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