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@misc{792821, author = {Matulová, Petra and Altmannová, Veronika and Marini Palomeque, María Victoria and Krejčí, Lumír}, keywords = {DNA repair; homologous recombination; nuclease activity; MUS81; SRS2}, language = {eng}, title = {Význam proteinů Srs2 a Mus81/MMS4 během opravy DNA.}, url = {http://www.sigmaaldrich.com/czech-republic/semin-225-345-e/seminare-20070/konference-mladych.html}, year = {2008} }
TY - GEN ID - 792821 AU - Matulová, Petra - Altmannová, Veronika - Marini Palomeque, María Victoria - Krejčí, Lumír PY - 2008 TI - Význam proteinů Srs2 a Mus81/MMS4 během opravy DNA. KW - DNA repair KW - homologous recombination KW - nuclease activity KW - MUS81 KW - SRS2 UR - http://www.sigmaaldrich.com/czech-republic/semin-225-345-e/seminare-20070/konference-mladych.html L2 - http://www.sigmaaldrich.com/czech-republic/semin-225-345-e/seminare-20070/konference-mladych.html N2 - Homologous recombination (HR) is a process widespread in nature and essential to maintain the integrity of the genome via repair of DNA double-strand breaks (DSBs). Several models were proposed to understand the mechanism of double-strand break repair by HR, identify separate steps and role of the individual proteins involved. The Mus81/MMS4 complex is a DNA structure-specific endonuclease involved in replication fork stability and DNA repair. It seems from genetic experiments that Mus81/MMS4 could interact with Srs2, a helicase which on one hand prevents untimely recombination and on the other hand is necessary for certain pathways of homologous recombination. In our study, we confirmed the interaction between Mus81/MMS4 and Srs2. We then analyzed the stimulation of Mus81/MMS4 nuclease activity by Srs2 and we found out that this stimulation depends on the DNA subtrate involved in the reaction. Our experiments also indicate that the interaction between Mus81/MMS4 and Srs2 is specific ER -
MATULOVÁ, Petra, Veronika ALTMANNOVÁ, María Victoria MARINI PALOMEQUE and Lumír KREJČÍ. \textit{Význam proteinů Srs2 a Mus81/MMS4 během opravy DNA. (Role of Srs2 and Mus81/MMS4 in processing recombination/replication intermediates)}. 2008.
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