| VAŘECHA, Miroslav, Michal ZIMMERMANN, Jana AMRICHOVÁ, Vladimír ULMAN, Pavel MATULA and Michal KOZUBEK. Prediction of localization and interactions of apoptotic proteins. Journal of Biomedical Science. BioMed website: BioMed Central, London, England, 2009, vol. 16, No 59, p. 1-14. ISSN 1021-7770. |
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@article{795881,
author = {Vařecha, Miroslav and Zimmermann, Michal and Amrichová, Jana and Ulman, Vladimír and Matula, Pavel and Kozubek, Michal},
article_location = {BioMed website},
article_number = {59},
keywords = {AIF;apoptosis-inducing factor;AMID;AIF-homologous mitochondrion-associated inducer of death;endonuclease G;heat shock protein;DNA topoisomerase II;CPS-6;CED-3 protease suppressor;WAH-1},
language = {eng},
issn = {1021-7770},
journal = {Journal of Biomedical Science},
title = {Prediction of localization and interactions of apoptotic proteins},
volume = {16},
year = {2009}
}
TY - JOUR
ID - 795881
AU - Vařecha, Miroslav - Zimmermann, Michal - Amrichová, Jana - Ulman, Vladimír - Matula, Pavel - Kozubek, Michal
PY - 2009
TI - Prediction of localization and interactions of apoptotic proteins
JF - Journal of Biomedical Science
VL - 16
IS - 59
SP - 1-14
EP - 1-14
PB - BioMed Central, London, England
SN - 10217770
KW - AIF;apoptosis-inducing factor;AMID;AIF-homologous mitochondrion-associated inducer of death;endonuclease G;heat shock protein;DNA topoisomerase II;CPS-6;CED-3 protease suppressor;WAH-1
N2 - We found the AMID protein to be cytoplasmic, most probably incorporated into the cytoplasmic side of the membranes of various organelles. The highest concentration of AMID was observed associated with the Golgi. We did not observe its translocation into the nucleus during apoptosis. The proposed role of AMID in apoptosis was thus not observed. Bioinformatic predictions were conducted to analyze the interactions of the studied proteins with each other and with other possible partners. We conducted molecular modelling of proteins with unknown 3D structure: endonuclease G, CPS-6, WAH-1, and HSP70-1. These models were then refined by MolProbity server and employed in molecular docking simulations of interactions. Our results present new data about the structure, localization, functions and interactions of proteins AMID, AIF, endonuclease G, and other proteins.
ER -
VAŘECHA, Miroslav, Michal ZIMMERMANN, Jana AMRICHOVÁ, Vladimír ULMAN, Pavel MATULA and Michal KOZUBEK. Prediction of localization and interactions of apoptotic proteins. \textit{Journal of Biomedical Science}. BioMed website: BioMed Central, London, England, 2009, vol.~16, No~59, p.~1-14. ISSN~1021-7770.
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