Detailed Information on Publication Record
2009
Prediction of localization and interactions of apoptotic proteins
VAŘECHA, Miroslav, Michal ZIMMERMANN, Jana AMRICHOVÁ, Vladimír ULMAN, Pavel MATULA et. al.Basic information
Original name
Prediction of localization and interactions of apoptotic proteins
Name in Czech
Predikce lokalizace a interakcí apoptotických proteinů
Authors
VAŘECHA, Miroslav (203 Czech Republic, guarantor, belonging to the institution), Michal ZIMMERMANN (203 Czech Republic, belonging to the institution), Jana AMRICHOVÁ (203 Czech Republic), Vladimír ULMAN (203 Czech Republic, belonging to the institution), Pavel MATULA (203 Czech Republic, belonging to the institution) and Michal KOZUBEK (203 Czech Republic, belonging to the institution)
Edition
Journal of Biomedical Science, BioMed website, BioMed Central, London, England, 2009, 1021-7770
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.007
RIV identification code
RIV/00216224:14330/09:00029126
Organization unit
Faculty of Informatics
UT WoS
000268893400002
Keywords in English
AIF;apoptosis-inducing factor;AMID;AIF-homologous mitochondrion-associated inducer of death;endonuclease G;heat shock protein;DNA topoisomerase II;CPS-6;CED-3 protease suppressor;WAH-1
Tags
AIF, AIFM1, AIFM2, AMID, apoptosis-inducing factor, CBIA, cbia-web, CED-3 protease suppressor, colocalization, CPS-6, DNA topoisomerase II, endoG, endonuclease G, heat shock protein, HSP70-1, Image analysis, interaction, localization, molecular docking, PDCD8, Prediction, PRG3, protein structure modelling, WAH-1, worm AIF homolog
Tags
International impact, Reviewed
Změněno: 7/1/2012 18:16, RNDr. Vladimír Ulman, Ph.D.
V originále
We found the AMID protein to be cytoplasmic, most probably incorporated into the cytoplasmic side of the membranes of various organelles. The highest concentration of AMID was observed associated with the Golgi. We did not observe its translocation into the nucleus during apoptosis. The proposed role of AMID in apoptosis was thus not observed. Bioinformatic predictions were conducted to analyze the interactions of the studied proteins with each other and with other possible partners. We conducted molecular modelling of proteins with unknown 3D structure: endonuclease G, CPS-6, WAH-1, and HSP70-1. These models were then refined by MolProbity server and employed in molecular docking simulations of interactions. Our results present new data about the structure, localization, functions and interactions of proteins AMID, AIF, endonuclease G, and other proteins.
In Czech
Predikce lokalizace a interakcí apoptotických proteinů
Links
| GP204/05/P090, research and development project |
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| LC535, research and development project |
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| MSM0021622419, plan (intention) |
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| 2B06052, research and development project |
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