Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats

KUČEROVÁ, Jana, Dagmar VRŠKOVÁ and Alexandra ŠULCOVÁ. Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats. In New Frontiers in the Research of PhD students: The 5th International Conference of Postgraduate Medical Students. Hradec Králové: Charles University in Prague, faculty of Medicine in Hradec Kralové, 2008, p. 20-21. ISBN 978-80-254-3384-3.

Basic information

• Original name: Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats
• Name in Czech: Vliv behaviorální sensitizace a hladiny estrogenů na "i.v. self-adminitration" metamfetaminu u potkana
• Authors: KUČEROVÁ, Jana, Dagmar VRŠKOVÁ and Alexandra ŠULCOVÁ.
• Edition: Hradec Králové, New Frontiers in the Research of PhD students: The 5th International Conference of Postgraduate Medical Students, p. 20-21, 2 pp. 2008.
• Publisher: Charles University in Prague, faculty of Medicine in Hradec Kralové

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• ISBN: 978-80-254-3384-3
• UT WoS: 000259593801380
• Keywords in English: methamphetamine; self-administration; behavioral sensitization; gender differences; rats
• Tags: behavioral sensitization, gender differences, methamphetamine, rats, self-administration
• Tags: International impact

Abstract

All the animals experienced previously with effects of MET in the phase of pretreatment showed the lower self-administered intake of MET. This might indicate that MET produced more profound rewarding effects in rats previously sensitized to the drug. The female groups in estrus-like conditions self-administered higher doses of MET than male groups with the same treatment however the females in anestrus self-administererd even lower doses than males. This indicates certain enhancing effect of estrogens on MET addiction in laboratory rodent model which is in accordance with other findings from animal and human studies.

Abstract (in Czech)

V sadě experimentů bylo prokázáno, že samci i samice ve fázi estru sensitizovaní premedikací MET přijímají vysoce signifikantně nižší dávku MET než nesensitizované skupiny zvířat. U všech sensitizovaných zvířat bylo ve srovnání s nesenzitizovanými jedinci zaznamenáno snížení (p<0.05) příjmu MET, které nebylo statisticky průkazné pouze u kastrovaných samic.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.