Repeated methamphetamine administration changes the relative expression of D1 receptor but not of D2 receptor in mouse midbrain

LANDA, Leoš and Michal JURAJDA. Repeated methamphetamine administration changes the relative expression of D1 receptor but not of D2 receptor in mouse midbrain. In Regional CINP Congress. 2008.

Basic information

• Original name: Repeated methamphetamine administration changes the relative expression of D1 receptor but not of D2 receptor in mouse midbrain
• Name in Czech: Opakovaná aplikace metamfetaminu mění relativní expresi D1 receptoru, nikoliv však D2 receptoru ve středním mozku myší
• Authors: LANDA, Leoš and Michal JURAJDA.
• Edition: Regional CINP Congress, 2008.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Slovakia
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• Keywords in English: methamphetamine; behavioural sensitization; PCR; mice; dopamine receptors
• Tags: behavioural sensitization, dopamine receptors, methamphetamine, mice, PCR

Abstract

The behavioural investigation showed stimulatory influence of methamphetamine (Met) after both acute administration and development of sensitization. Met administration increased D1 mRNA expression; non-significantly after the first dose and significantly (p<0.006) after the challenge dose. Changes in D2 mRNA expression were not significant at all, which is to certain extent in agreement with other reports suggesting that there is no clear information whether the interaction of D1 and D2 receptors can produce a cooperative or synergistic effect on reinforcement processes

Abstract (in Czech)

Behaviorální část experimentu ukázala stimulující vliv metamfetaminu (Met) jak po akutní aplikaci, tak po rozvoji senzitizace. Aplikace Met zvýšila expresi D1 mRNA; nesignifikantně po první dávce a signifikantně (p<0,006) po provokující dávce. Změny exprese D2 mRNA nebyly signifikantní vůbec, což do jisté míry souhlasí s jinými údaji, které naznačují, že neexistuje jednoznačná informace, jestli interakce D1 a D2 receptorů může produkovat synergický vliv v procesech posílení.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.