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@inproceedings{799688,
author = {Pistovčáková, Jana and Němeček, Michal and Šulcová, Alexandra},
address = {Bratislava},
booktitle = {Regional CINP Congress},
keywords = {aripiprazole; animal model; depression; behaviour; immunity},
language = {eng},
location = {Bratislava},
pages = {49-49},
publisher = {Collegium Internationale Neuro-psychopharmacologicum},
title = {Preclinical experience of the antidepressant effect of aripiprazole},
year = {2008}
}
TY - JOUR
ID - 799688
AU - Pistovčáková, Jana - Němeček, Michal - Šulcová, Alexandra
PY - 2008
TI - Preclinical experience of the antidepressant effect of aripiprazole
PB - Collegium Internationale Neuro-psychopharmacologicum
CY - Bratislava
KW - aripiprazole
KW - animal model
KW - depression
KW - behaviour
KW - immunity
N2 - Antipsychotic aripiprazole, a dopamine D2 receptor ligand, has a number of other possible mechanisms of action including its action at serotonin (5-HT) and adrenergic receptors, that may be important in the treatment of depressive disorders. Preclinical studies demonstrate the immunotropic effects of atypical neuroleptics. In the present study the well-established olfactory bulbectomy (OB) rat model of experimental depression was used. Our study was aimed to address the question of the behavioural effect of aripiprazole and its possible effect on the cell immune function. Aripiprazole exhibited a significant positive influence on the impaired leukocyte phagocytosis in the OB rats serving as model of depression without any effect on this cellular immunological parameter in the sham-operated controls.
ER -
PISTOVČÁKOVÁ, Jana, Michal NĚMEČEK a Alexandra ŠULCOVÁ. Preclinical experience of the antidepressant effect of aripiprazole. Online. In \textit{Regional CINP Congress}. Bratislava: Collegium Internationale Neuro-psychopharmacologicum, 2008. s.~49. [citováno 2024-04-23]
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