Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression

PISTOVČÁKOVÁ, Jana, Miroslav DOSTÁLEK, Alexandra ŠULCOVÁ and Daniela JEŽOVÁ. Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression. Pharmacopsychiatry. Stuttgart-New York: Georg Thieme Verlag KG, 2008, vol. 41, No 2, p. 54-59. ISSN 0176-3679.

Basic information

Original name

Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression

Name in Czech

Aplikace tiagabinu je spojená s neurochemickými a imunitními změnami a alterací chování v potkaním modelu deprese

Authors

PISTOVČÁKOVÁ, Jana, Miroslav DOSTÁLEK, Alexandra ŠULCOVÁ and Daniela JEŽOVÁ

Edition

Pharmacopsychiatry, Stuttgart-New York, Georg Thieme Verlag KG, 2008, 0176-3679

---

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.402

Organization unit

Faculty of Medicine

UT WoS

000254356200003

Keywords in English

tiagabine; olfactory bulbectomy; rat; immunity; behaviour; endocrine

Tags

behaviour, endocrine, immunity, olfactory bulbectomy, rat, tiagabine

Tags

International impact, Reviewed

---

Abstract

V originále

The purpose of the study was to test a potential antidepressant effect of the 3rd generation antiepileptic tiagabine in rats chronically stressed by anosmia due to bilateral olfactory bulbectomy (OB), which is a well-established animal model of human depression resembling behavioural, immune and endocrine changes (Leonard and Tuite, 1981). OB rats show significant increase in locomotor/exploratory activities in the open-field test, and altered plasma stress hormone levels and suppressed phagocytosis of leukocytes what we have examined in the present experiments. After repeated tiagabine (12 mg/kg/day, IP) administration we measured the locomotor activity in the open-field test, adrenalin, noradrenaline, dopamine and corticosterone plasma levels and the leukocyte phagocytic function. Also the differential white blood cell counts were measured. Repeated tiagabine treatment elicited a significant decrease of the locomotor hyperactivity in the open field test. Taking into account that clinically approved antidepressants reverse OB related behavioural and immune disorders (Leonard and Tuite, 1981) the results indicate the hypothesized antidepressant activity of tiagabine. The OB-induced changes in leukocyte differential counts were not found in the tiagabine-treated group. The OB-induced reduction in plasma noradrenaline levels was normalised following tiagabine treatment.

In Czech

Cílem práce bylo studium potenciálních antidepresivních účinků tiagabinu s využitím potkaního modelu deprese - bilaterální olfaktorické bulbektomie (OB). Sledovali jsme změny lokomotorické aktivity OB potkanu v testu volného pole, změny fagocytární aktivity leukocytů a změny hladin stresových hormonů (noradrenalinu, adrenalinu, dopaminu a kortikosteronu). Opakované podávání tiagabinu (12 mg/kg/day, IP) vedlo k normalizaci chování OB zvířat. Snížená hladina noradrenalinu v modelu deprese byla také normalizována po tiagabinu.

---

Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.