ZENDULKA, Ondřej, Lucia ZAHRADNÍKOVÁ, Jan JUŘICA and Jiří TOTUŠEK. The Influence of Trans-resveratrol and Quercetin on the Activity of CYP1A2 in Rat. Czech Journal of Food Science. 2008, vol. 26, 00-00, p. S60-S64, 5 pp. ISSN 1212-1800.
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Basic information
Original name The Influence of Trans-resveratrol and Quercetin on the Activity of CYP1A2 in Rat
Name in Czech Vliv trans-resveratrolu a kvercetinu na aktivitu CYP1A2 u potkana
Name (in English) The Influence of Trans-resveratrol and Quercetin on the Activity of CYP1A2 in Rat
Authors ZENDULKA, Ondřej (203 Czech Republic, guarantor), Lucia ZAHRADNÍKOVÁ (703 Slovakia), Jan JUŘICA (203 Czech Republic) and Jiří TOTUŠEK (203 Czech Republic).
Edition Czech Journal of Food Science, 2008, 1212-1800.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.472
RIV identification code RIV/00216224:14110/08:00025115
Organization unit Faculty of Medicine
UT WoS 000266082000011
Keywords in English cytochrome P450; trans-revseratrol; quercetin; perfused rat liver
Tags cytochrome P450, perfused rat liver, quercetin, trans-revseratrol
Changed by Changed by: RNDr. Jiří Totušek, CSc., učo 850. Changed: 26/6/2009 10:29.
Abstract
Polyphenolic compounds are widely distributed among plants and are present also in wine grapes and wine. We determined the influence of polyphenols (trans-resveratrol, quercetin) and sex on the activity of cytochrome P450 in rats. Cytochrome P450 (CYP450) is one of the most important enzymatic systems of biotransformation. Its activity is influenced by many endo- as well as exogenous factors. In our experiment we studied on the model of perfused rat liver the activity of 1A2 isoenzyme, which is being linked with the activation of promutagenes and procarcinogenes. Our results confirmed different metabolic acivity between males and females. Female rats metabolized faster through CYP1A2. Trans-resveratrol didn't influence the activity of CYP1A2, but it enhanced intersexual differences. Based on our results we suggest, that quercetin is an inhibitor of CYP1A2 isoenzyme.
Abstract (in English)
Polyphenolic compounds are widely distributed among plants and are present also in wine grapes and wine. We determined the influence of polyphenols (trans-resveratrol, quercetin) and sex on the activity of cytochrome P450 in rats. Cytochrome P450 (CYP450) is one of the most important enzymatic systems of biotransformation. Its activity is influenced by many endo- as well as exogenous factors. In our experiment we studied on the model of perfused rat liver the activity of 1A2 isoenzyme, which is being linked with the activation of promutagenes and procarcinogenes. Our results confirmed different metabolic acivity between males and females. Female rats metabolized faster through CYP1A2. Trans-resveratrol didn't influence the activity of CYP1A2, but it enhanced intersexual differences. Based on our results we suggest, that quercetin is an inhibitor of CYP1A2 isoenzyme.
Links
GA525/06/1757, research and development projectName: Polyfenolické látky hroznů, révových vín a jejich antimutagenní a antioxidační vlastnosti
Investor: Czech Science Foundation
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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