Survival and infertility treatment in male cancer patients after sperm banking

CRHA, Igor, Pavel VENTRUBA, Martin HUSER, Jana ŽÁKOVÁ, Robert HUDEČEK and Jiří JARKOVSKÝ. Survival and infertility treatment in male cancer patients after sperm banking. Fertility and Sterility. 2009, vol. 91, No 6, p. 2344-2348. ISSN 1556-5653.

Basic information

• Original name: Survival and infertility treatment in male cancer patients after sperm banking
• Name in Czech: Survival and infertility treatment in male cancer patients after sperm banking
• Authors: CRHA, Igor (203 Czech Republic, guarantor, belonging to the institution), Pavel VENTRUBA (203 Czech Republic, belonging to the institution), Martin HUSER (203 Czech Republic, belonging to the institution), Jana ŽÁKOVÁ (203 Czech Republic, belonging to the institution), Robert HUDEČEK (203 Czech Republic, belonging to the institution) and Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution).
• Edition: Fertility and Sterility, 2009, 1556-5653.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30214 Obstetrics and gynaecology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.970
• RIV identification code: RIV/00216224:14110/09:00034393
• Organization unit: Faculty of Medicine
• UT WoS: 000266801400009
• Keywords (in Czech): cryopreservation; semen; cancer survivors; male infertility
• Keywords in English: cryopreservation; semen; cancer survivors; male infertility
• Tags: International impact, Reviewed

Abstract

OBJECTIVE: The main aim of the study was to evaluate the relationship between sperm pathology and cancer diagnosis, determine the mortality rate, and evaluate the outcomes of the use of frozen sperm from the sperm bank. DESIGN: Prospective study. SETTING: University fertility center. PATIENT(S): A total of 619 male patients were referred for sperm freezing before gonadotoxic therapy from 1995 to 2006. INTERVENTION(S): Semen analysis, data verification in the National Oncological Register, assisted reproduction techniques, statistical evaluation. MAIN OUTCOME MEASURE(S): Cancer diagnosis and sperm pathology analysis, survival of patients and infertility treatment. RESULT(S): Malignant testicular cancer was diagnosed in 43.6% of patients, while malignant neoplasms of the lymphatic and haematopoietic tissues were found in 31.7% of patients. Azoospermia, or severe oligospermia were detected in 9.7% and 22.6% of patients, respectively. Until now, 32 patients (5.2%) have attended for infertility treatment. Cryopreserved semen was used in 28 couples (87.5%), 44 ICSI cycles resulted in 13 pregnancies. In total, 74 deaths (11.9%) were reported, 61 of them (82.4%) within 30 months of the cryopreservation of their sperm. CONCLUSION(S): Significant number of patients survived. Intrauterine insemination and ICSI with cryopreserved sperm resulted in deliveries.

Abstract (in Czech)

OBJECTIVE: The main aim of the study was to evaluate the relationship between sperm pathology and cancer diagnosis, determine the mortality rate, and evaluate the outcomes of the use of frozen sperm from the sperm bank. DESIGN: Prospective study. SETTING: University fertility center. PATIENT(S): A total of 619 male patients were referred for sperm freezing before gonadotoxic therapy from 1995 to 2006. INTERVENTION(S): Semen analysis, data verification in the National Oncological Register, assisted reproduction techniques, statistical evaluation. MAIN OUTCOME MEASURE(S): Cancer diagnosis and sperm pathology analysis, survival of patients and infertility treatment. RESULT(S): Malignant testicular cancer was diagnosed in 43.6% of patients, while malignant neoplasms of the lymphatic and haematopoietic tissues were found in 31.7% of patients. Azoospermia, or severe oligospermia were detected in 9.7% and 22.6% of patients, respectively. Until now, 32 patients (5.2%) have attended for infertility treatment. Cryopreserved semen was used in 28 couples (87.5%), 44 ICSI cycles resulted in 13 pregnancies. In total, 74 deaths (11.9%) were reported, 61 of them (82.4%) within 30 months of the cryopreservation of their sperm. CONCLUSION(S): Significant number of patients survived. Intrauterine insemination and ICSI with cryopreserved sperm resulted in deliveries.

Links

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)