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@article{806884,
author = {Szüčová, L. and Trávníček, Z. and Popa, I. and Marek, Jaromír},
article_location = {Velká Británie},
article_number = {12},
keywords = {Pt(II) complexes; cytokinins; NMR spectroscopy; X-ray structures; in vitro cytotoxicity},
language = {eng},
issn = {0277-5387},
journal = {Polyhedron},
title = {Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography},
volume = {27},
year = {2008}
}
TY - JOUR
ID - 806884
AU - Szüčová, L. - Trávníček, Z. - Popa, I. - Marek, Jaromír
PY - 2008
TI - Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography
JF - Polyhedron
VL - 27
IS - 12
SP - 2710-2720
EP - 2710-2720
PB - PERGAMON-ELSEVIER SCIENCE LTD, OXFORD
SN - 02775387
KW - Pt(II) complexes
KW - cytokinins
KW - NMR spectroscopy
KW - X-ray structures
KW - in vitro cytotoxicity
N2 - Mononuclear, square-planar platinum(II) complexes involving derivatives of aromatic cytokinins as the ligands, and having the general formula cis-[Pt(L-n)(2)Cl-2] (1-3) and trans-[Pt(L-n)(2)Cl-2] (4-6), where n = 13, L-1 = 2-chloro-6-(benzylamino)-9-isopropylpurine, L-2 = 2-chloro-6-[(4-methoxybenzyl)amino]-9-isopropylpurine and L-3 = 2-chloro-6-[(2-methoxybenzyl)-amino]-9-isopropylpurine, have been synthesized and characterized by elemental analysis, MALDI-TOF mass, FT IR, H-1, C-13, N-15 and Pt-195 NMR spectral measurements. Dynamic cis-to-trans isomerization process of complex 1 in N,N'-dimethylformamide (DMF) has been investigated by means of multinuclear NMR spectroscopy. The solid-state structures of 1, 4 center dot (DMF)(2), and 5 have been determined by single crystal X-ray analysis. X-ray structures revealed that the heterocyclic ligands are coordinated to platinum via nitrogen atom N(7) in all the complexes studied. In vitro cytotoxicity of the prepared complexes against MCF7, G361, K562, and HOS has been evaluated. Owing to low solubility of the complexes in water, the cytotoxicity has been only tested up to 5 mu M concentration. Unfortunately, all complexes have been found to be non-cytotoxic in the accessible concentration range.
ER -
SZÜČOVÁ, L., Z. TRÁVNÍČEK, I. POPA a Jaromír MAREK. Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography. \textit{Polyhedron}. Velká Británie: PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, 2008, roč.~27, č.~12, s.~2710-2720. ISSN~0277-5387.
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