Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography

SZÜČOVÁ, L., Z. TRÁVNÍČEK, I. POPA and Jaromír MAREK. Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography. Polyhedron. Velká Británie: PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, vol. 27, No 12, p. 2710-2720. ISSN 0277-5387. 2008.

Basic information

• Original name: Preparation and cis-to-trans transformation study of square-planar [Pt(L-n)2Cl(2)] complexes bearing cytokinins derived from 6-benzylaminopurine (L-n) by view of NMR spectroscopy and X-ray crystallography
• Name in Czech: Příprava a cis-trans transformace čtvercově-planárních platnatých komplexů s benzylaminopurinovými cytokininy očima NMR spektroskopie a RTG strukturní analýzy
• Authors: SZÜČOVÁ, L. (203 Czech Republic), Z. TRÁVNÍČEK (203 Czech Republic), I. POPA (498 Republic of Moldova) and Jaromír MAREK (203 Czech Republic, guarantor).
• Edition: Polyhedron, Velká Británie, PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, 2008, 0277-5387.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10402 Inorganic and nuclear chemistry
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.801
• RIV identification code: RIV/00216224:14310/08:00027229
• Organization unit: Faculty of Science
• UT WoS: 000258616400029
• Keywords in English: Pt(II) complexes; cytokinins; NMR spectroscopy; X-ray structures; in vitro cytotoxicity
• Tags: cytokinins, in vitro cytotoxicity, NMR Spectroscopy, Pt(II) complexes, x-ray structures
• Tags: Reviewed

Abstract

Mononuclear, square-planar platinum(II) complexes involving derivatives of aromatic cytokinins as the ligands, and having the general formula cis-[Pt(L-n)(2)Cl-2] (1-3) and trans-[Pt(L-n)(2)Cl-2] (4-6), where n = 13, L-1 = 2-chloro-6-(benzylamino)-9-isopropylpurine, L-2 = 2-chloro-6-[(4-methoxybenzyl)amino]-9-isopropylpurine and L-3 = 2-chloro-6-[(2-methoxybenzyl)-amino]-9-isopropylpurine, have been synthesized and characterized by elemental analysis, MALDI-TOF mass, FT IR, H-1, C-13, N-15 and Pt-195 NMR spectral measurements. Dynamic cis-to-trans isomerization process of complex 1 in N,N'-dimethylformamide (DMF) has been investigated by means of multinuclear NMR spectroscopy. The solid-state structures of 1, 4 center dot (DMF)(2), and 5 have been determined by single crystal X-ray analysis. X-ray structures revealed that the heterocyclic ligands are coordinated to platinum via nitrogen atom N(7) in all the complexes studied. In vitro cytotoxicity of the prepared complexes against MCF7, G361, K562, and HOS has been evaluated. Owing to low solubility of the complexes in water, the cytotoxicity has been only tested up to 5 mu M concentration. Unfortunately, all complexes have been found to be non-cytotoxic in the accessible concentration range.

Abstract (in Czech)

V práci byly studovány čtvercově planární platnaté komplexy s aromatickými cytokininy jako ligandy metodami MALDI, FTR a multijadernou NMR. U vybraných - krystalizovatelných - komplexů byly určeny i jejich 3D krystalové struktury.

Links

• MSM0021622410, plan (intention): Name: Fyzikální a chemické vlastnosti pokročilých materiálů a struktur

Investor: Ministry of Education, Youth and Sports of the CR, Physical and chemical properties of advanced materials and structures