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@article{807185,
author = {Šimurda, Jiří and Pásek, Michal and Šimurdová, Milena},
article_location = {Brno},
article_number = {1},
keywords = {Cardiac cell; Action voltage; Resolution into components; Transferred electrical charges},
language = {eng},
issn = {1211-412X},
journal = {Analysis of Biomedical Signals and Images},
title = {Resolution of action voltage of cardiac cells into components represented by transferred charges},
volume = {19},
year = {2008}
}
TY - JOUR
ID - 807185
AU - Šimurda, Jiří - Pásek, Michal - Šimurdová, Milena
PY - 2008
TI - Resolution of action voltage of cardiac cells into components represented by transferred charges
JF - Analysis of Biomedical Signals and Images
VL - 19
IS - 1
SP - 1-4
EP - 1-4
PB - Vutium Press
SN - 1211412X
KW - Cardiac cell
KW - Action voltage
KW - Resolution into components
KW - Transferred electrical charges
N2 - Action voltage of cardiac cells is expressed as a sum of particular components representing contributions of individual ionic currents in terms of electrical charges transferred across cell membrane. Biophysical models describing electrical membrane phenomena in rat and human ventricular cardiomyocytes by sets of nonlinear differential equations are used to verify the proposed approach. Computer simulations indicated that in rat model action voltage waveform is largely formed by three current components: L-type calcium current ICa, fast sodium current INa, and transient outward current IKto. In contrast, in human ventricular cell, participation of other components is much more significant. Particularly, the currents generated by electrogenic carrier mechanisms Na-Ca, Na-K and sarcolemmal Ca-pump play an important role.
ER -
ŠIMURDA, Jiří, Michal PÁSEK and Milena ŠIMURDOVÁ. Resolution of action voltage of cardiac cells into components represented by transferred charges. \textit{Analysis of Biomedical Signals and Images}. Brno: Vutium Press, 2008, vol.~19, No~1, p.~1-4. ISSN~1211-412X.
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