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@article{807185, author = {Šimurda, Jiří and Pásek, Michal and Šimurdová, Milena}, article_location = {Brno}, article_number = {1}, keywords = {Cardiac cell; Action voltage; Resolution into components; Transferred electrical charges}, language = {eng}, issn = {1211-412X}, journal = {Analysis of Biomedical Signals and Images}, title = {Resolution of action voltage of cardiac cells into components represented by transferred charges}, volume = {19}, year = {2008} }
TY - JOUR ID - 807185 AU - Šimurda, Jiří - Pásek, Michal - Šimurdová, Milena PY - 2008 TI - Resolution of action voltage of cardiac cells into components represented by transferred charges JF - Analysis of Biomedical Signals and Images VL - 19 IS - 1 SP - 1-4 EP - 1-4 PB - Vutium Press SN - 1211412X KW - Cardiac cell KW - Action voltage KW - Resolution into components KW - Transferred electrical charges N2 - Action voltage of cardiac cells is expressed as a sum of particular components representing contributions of individual ionic currents in terms of electrical charges transferred across cell membrane. Biophysical models describing electrical membrane phenomena in rat and human ventricular cardiomyocytes by sets of nonlinear differential equations are used to verify the proposed approach. Computer simulations indicated that in rat model action voltage waveform is largely formed by three current components: L-type calcium current ICa, fast sodium current INa, and transient outward current IKto. In contrast, in human ventricular cell, participation of other components is much more significant. Particularly, the currents generated by electrogenic carrier mechanisms Na-Ca, Na-K and sarcolemmal Ca-pump play an important role. ER -
ŠIMURDA, Jiří, Michal PÁSEK and Milena ŠIMURDOVÁ. Resolution of action voltage of cardiac cells into components represented by transferred charges. \textit{Analysis of Biomedical Signals and Images}. Brno: Vutium Press, 2008, vol.~19, No~1, p.~1-4. ISSN~1211-412X.
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