Detailed Information on Publication Record
2008
Multivariate analysis of risk factors for testicular cancer: a hospital-based case-control study in the Czech Republic
DUŠEK, Ladislav, Jitka ABRAHÁMOVÁ, Radek LAKOMÝ, Rostislav VYZULA, Jana KOPTÍKOVÁ et. al.Basic information
Original name
Multivariate analysis of risk factors for testicular cancer: a hospital-based case-control study in the Czech Republic
Name in Czech
Vícerozměrná analýza rizikových faktorů karcinomu varlat: případová studie pacientů v ČR
Name (in English)
Multivariate analysis of risk factors for testicular cancer: a hospital-based case-control study in the Czech Republic
Authors
DUŠEK, Ladislav (203 Czech Republic, guarantor), Jitka ABRAHÁMOVÁ (203 Czech Republic), Radek LAKOMÝ (203 Czech Republic), Rostislav VYZULA (203 Czech Republic), Jana KOPTÍKOVÁ (203 Czech Republic), Tomáš PAVLÍK (203 Czech Republic), Jan MUŽÍK (203 Czech Republic) and Daniel KLIMEŠ (203 Czech Republic)
Edition
NEOPLASMA, SLOVAKIA, VEDA, SLOVAK ACAD SCIENCES, 2008, 0028-2685
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.179
RIV identification code
RIV/00216224:14110/08:00034569
Organization unit
Faculty of Medicine
UT WoS
000257128400014
Keywords (in Czech)
nádory varlat; rizikové faktory; případová studie
Keywords in English
testicular cancer; risk factors; case-control study
Tags
Reviewed
Změněno: 24/6/2009 15:17, RNDr. Tomáš Pavlík, Ph.D.
V originále
Growing incidence of testicular cancer around the world stimulates research attempting to explain the trends. This study quantified the contribution of different types of potential risk factors for testicular germ-cell cancer (TGCC) with differentiation between seminoma and non-seminoma. A standardized questionnaire containing demographic data, pre- and perinatal factors, social, lifestyle and occupational parameters was prepared. The data file consists of n = 356 TGCCs (seminoma: n = 195; non-seminoma: n = 161) and n = 317 controls, frequency matched on age to cases. The following factors were significantly associated with the risk of TGCCs in univariate analyses (ORs): atrophic testis (5.3), smoking over 12 pack-yr (4.9), cryptorchidism (2.9), testicular trauma (2.0), birth weight under 3,000 g (1.6), low degree of education (3.0) in correlation with manual occupation (2.3) and finally, overall familial cancer history (1.5) and familial history of breast (1.8) and prostate cancer (3.9). On the other hand, maternal age over 20 yr (OR < 0.4) and moderate recreational sport activity (OR = 0.5) significantly reduced the risk of TGCCs. A significant risk was associated with cryptorchidism (OR = 2.9; 95% CI = 1.5-5.9) where orchidopexy was delayed after 5 yr of age (OR = 5.2; 95% CI = 1.5-18.1). Delayed orchidopexy was associated namely with the risk of seminomas (OR = 7.5; 95% CI = 2.1-26.7). Only some of the variables were retained in multivariate model for TGCCs as well as for histological subtypes (multivariate adjusted OR for all TGCCs): atrophic testis (5.9), family history of prostate cancer (4.8), cryptorchidism (3.8) and interaction term 'low degree of education & manual occupation' (3.0). Familial history of breast cancer elevated risk of TGCCs and of seminomas (OR: 2.01-2.18). Birth weight under 3,000 g was retained in a multivariate model for TGCCs with a borderline significance (OR = 1.67). We could not rule out any type of risk factors, as each one was significantly represented in the final multivariate models. Familial cancer history remained to be an influential risk factor, altogether with some lifestyle and occupational parameters. This suggests that both environmental exposures and genetic inheritance can play role in the moderation of the risk of TGCC.
In English
Growing incidence of testicular cancer around the world stimulates research attempting to explain the trends. This study quantified the contribution of different types of potential risk factors for testicular germ-cell cancer (TGCC) with differentiation between seminoma and non-seminoma. A standardized questionnaire containing demographic data, pre- and perinatal factors, social, lifestyle and occupational parameters was prepared. The data file consists of n = 356 TGCCs (seminoma: n = 195; non-seminoma: n = 161) and n = 317 controls, frequency matched on age to cases. The following factors were significantly associated with the risk of TGCCs in univariate analyses (ORs): atrophic testis (5.3), smoking over 12 pack-yr (4.9), cryptorchidism (2.9), testicular trauma (2.0), birth weight under 3,000 g (1.6), low degree of education (3.0) in correlation with manual occupation (2.3) and finally, overall familial cancer history (1.5) and familial history of breast (1.8) and prostate cancer (3.9). On the other hand, maternal age over 20 yr (OR < 0.4) and moderate recreational sport activity (OR = 0.5) significantly reduced the risk of TGCCs. A significant risk was associated with cryptorchidism (OR = 2.9; 95% CI = 1.5-5.9) where orchidopexy was delayed after 5 yr of age (OR = 5.2; 95% CI = 1.5-18.1). Delayed orchidopexy was associated namely with the risk of seminomas (OR = 7.5; 95% CI = 2.1-26.7). Only some of the variables were retained in multivariate model for TGCCs as well as for histological subtypes (multivariate adjusted OR for all TGCCs): atrophic testis (5.9), family history of prostate cancer (4.8), cryptorchidism (3.8) and interaction term 'low degree of education & manual occupation' (3.0). Familial history of breast cancer elevated risk of TGCCs and of seminomas (OR: 2.01-2.18). Birth weight under 3,000 g was retained in a multivariate model for TGCCs with a borderline significance (OR = 1.67). We could not rule out any type of risk factors, as each one was significantly represented in the final multivariate models. Familial cancer history remained to be an influential risk factor, altogether with some lifestyle and occupational parameters. This suggests that both environmental exposures and genetic inheritance can play role in the moderation of the risk of TGCC.
Links
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