| PALEČEK, Emil, Marie BRÁZDOVÁ, Hana ČERNOCKÁ, Daniel VLK, Václav BRÁZDA a Bořivoj VOJTĚŠEK. Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments. Oncogene. Basingstoke: Macmillan Press, 1999, roč. 24, č. 18, s. 3617-3625. ISSN 0950-9232. |
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@article{815761,
author = {Paleček, Emil and Brázdová, Marie and Černocká, Hana and Vlk, Daniel and Brázda, Václav and Vojtěšek, Bořivoj},
article_location = {Basingstoke},
article_number = {18},
keywords = {p53; DNA-p53 interaction; scDNA; divalent cation; gel electrophoresis},
language = {eng},
issn = {0950-9232},
journal = {Oncogene},
title = {Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments},
volume = {24},
year = {1999}
}
TY - JOUR
ID - 815761
AU - Paleček, Emil - Brázdová, Marie - Černocká, Hana - Vlk, Daniel - Brázda, Václav - Vojtěšek, Bořivoj
PY - 1999
TI - Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments
JF - Oncogene
VL - 24
IS - 18
SP - 3617-3625
EP - 3617-3625
PB - Macmillan Press
SN - 09509232
KW - p53
KW - DNA-p53 interaction
KW - scDNA
KW - divalent cation
KW - gel electrophoresis
N2 - Recently we have shown that wild-type human p53 protein binds preferentially to supercoiled (sc) DNA in vitro in both the presence and absence of the p53 consensus sequence (p53CON). This binding produces a ladder of retarded bands on an agarose gel. The intensity and the number of these hands are decreased by physiological concentrations of zinc ions. At higher zinc concentrations, binding of p53 to scDNA is completely inhibited.
ER -
PALEČEK, Emil, Marie BRÁZDOVÁ, Hana ČERNOCKÁ, Daniel VLK, Václav BRÁZDA a Bořivoj VOJTĚŠEK. Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments. \textit{Oncogene}. Basingstoke: Macmillan Press, 1999, roč.~24, č.~18, s.~3617-3625. ISSN~0950-9232.
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