Exprese genů pro dopaminové D1, 2 receptory v myším mesencephalonu po zkřížené senzitizaci kanabinoidem k metamfetaminu

LANDA, Leoš and Michal JURAJDA. Exprese genů pro dopaminové D1, 2 receptory v myším mesencephalonu po zkřížené senzitizaci kanabinoidem k metamfetaminu (Changes in gene expression of dopamine D1, 2 receptors in mouse mesencephalon after cannabinoid cross-sensitization to methamphetamine). Psychiatrie. Praha: Tigis, 2009, vol. 13, Suppl. 1, p. 48-48. ISSN 1211-7579.

Basic information

• Original name: Exprese genů pro dopaminové D1, 2 receptory v myším mesencephalonu po zkřížené senzitizaci kanabinoidem k metamfetaminu
• Name in Czech: Exprese genů pro dopaminové D1, 2 receptory v myším mesencephalonu po zkřížené senzitizaci kanabinoidem k metamfetaminu
• Name (in English): Changes in gene expression of dopamine D1, 2 receptors in mouse mesencephalon after cannabinoid cross-sensitization to methamphetamine
• Authors: LANDA, Leoš and Michal JURAJDA.
• Edition: Psychiatrie, Praha, Tigis, 2009, 1211-7579.

Other information

• Original language: Czech
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• Keywords in English: behavioural sensitization; methanandamide; methamphetamine; PCR; dopamine receptor; mice
• Tags: behavioural sensitization, dopamine receptor, methamphetamine, methanandamide, mice, PCR

Abstract

Behaviorálně byl potvrzen rozvoj jak přímé, tak zkřížené sensitizace k metamfetaminu. Výsledky qPCR prokázaly u těchto zvířat zvýšenou expresi D1 mRNA. Změny exprese D2 mRNA nebyly signifikantní, což je do jisté míry v souladu s jinými údaji jež neprokázaly obdobný podíl D1 a D2 receptorů na míře "posilujícího" účinku ("reinforcement") látky.

Abstract (in English)

The behavioural part of the study confirmed both behavioural sensitization and cross-sensitization to methamphetamine. Results from qPCR showed in these animals increase in D1 mRNA expression. Changes in D2 mRNA expression were not significant at all, which is to certain extent in agreement with other reports suggesting that there is no clear information whether the interaction of D1 and D2 receptors can produce a cooperative effect on reinforcement processes.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.