Detailed Information on Publication Record
2009
Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes
KREJČÍ, Pavel, Jiřina PROCHÁZKOVÁ, Vítězslav BRYJA, Petra JELÍNKOVÁ, Kateřina PEJCHALOVÁ et. al.Basic information
Original name
Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes
Name in Czech
Fibroblastový růstový faktor inhibuje signální dráhy interferonu gama-STAT1 a interleukinu 6-STAT3 v chondrocytech
Authors
KREJČÍ, Pavel (203 Czech Republic, guarantor, belonging to the institution), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution), Vítězslav BRYJA (203 Czech Republic, belonging to the institution), Petra JELÍNKOVÁ (203 Czech Republic, belonging to the institution), Kateřina PEJCHALOVÁ (203 Czech Republic), Alois KOZUBÍK (203 Czech Republic, belonging to the institution), Leslie Michels TOMPSON (840 United States of America) and William R. WILCOX (840 United States of America)
Edition
Cellular Signalling, 2009, 0898-6568
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 4.094
RIV identification code
RIV/00216224:14310/09:00034796
Organization unit
Faculty of Science
UT WoS
000262060900019
Keywords in English
fibroblast growth factor; cartilage; STAT1; STAT3; chondrocyte; cytokine; inhibition
Změněno: 20/3/2012 13:52, Mgr. Jiřina Medalová, Ph.D.
V originále
Activation of FGFR3 leads to attenutation of cartilage growth. We evidence that FGF stimulus leads to accumulation of STAT1, 3, 5, 6 both in chondrocyte model and murine limb explant cultures. Despite this accummulation, STAT 1, and 3 signaling pathways are impaired by FGF. FGF increases also expression of CIS, SOCS1, and SOCS3, inhibitors of IL6 receptor signaling and thus may contribute to the growth-inhibitory effect of FGFR3 signaling in cartilage.
In Czech
Aktivace FGFR3 vede k utlumení růstu chrupavky. Zjistili jsme, že FGF stimulus vede k akumulaci STAT1, 3, 5, 6, jak v modelu chondrocytárních buněk, tak v explantátech myších končetin. Přes tuto akumulaci bylo dokázáno, že signální dráhy STAT 1 a 3 nejsou funkční. FGF zvyšuje také expresi inhibitorů IL-6 signální dráhy CIS, SOCS1 a SOCS3, což může být jednou z příčin utlumení růstu chrupavky vlivem FGFR3 signálování.
Links
| MSM0021622415, plan (intention) |
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