KREJČÍ, Pavel, Jiřina PROCHÁZKOVÁ, Vítězslav BRYJA, Petra JELÍNKOVÁ, Kateřina PEJCHALOVÁ, Alois KOZUBÍK, Leslie Michels TOMPSON and William R. WILCOX. Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. Online. Cellular Signalling. 2009, vol. 21, No 1, p. 151-160. ISSN 0898-6568. Available from: https://dx.doi.org/10.1016/j.cellsig.2008.10.006. [citováno 2024-04-24]
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes
Name in Czech Fibroblastový růstový faktor inhibuje signální dráhy interferonu gama-STAT1 a interleukinu 6-STAT3 v chondrocytech
Authors KREJČÍ, Pavel (203 Czech Republic, guarantor, belonging to the institution), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution), Vítězslav BRYJA (203 Czech Republic, belonging to the institution), Petra JELÍNKOVÁ (203 Czech Republic, belonging to the institution), Kateřina PEJCHALOVÁ (203 Czech Republic), Alois KOZUBÍK (203 Czech Republic, belonging to the institution), Leslie Michels TOMPSON (840 United States of America) and William R. WILCOX (840 United States of America)
Edition Cellular Signalling, 2009, 0898-6568.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.094
RIV identification code RIV/00216224:14310/09:00034796
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1016/j.cellsig.2008.10.006
UT WoS 000262060900019
Keywords in English fibroblast growth factor; cartilage; STAT1; STAT3; chondrocyte; cytokine; inhibition
Tags cartilage, chondrocyte, cytokine, fibroblast growth factor, inhibition, STAT1, STAT3
Changed by Changed by: Mgr. Jiřina Medalová, Ph.D., učo 176525. Changed: 20/3/2012 13:52.
Abstract
Activation of FGFR3 leads to attenutation of cartilage growth. We evidence that FGF stimulus leads to accumulation of STAT1, 3, 5, 6 both in chondrocyte model and murine limb explant cultures. Despite this accummulation, STAT 1, and 3 signaling pathways are impaired by FGF. FGF increases also expression of CIS, SOCS1, and SOCS3, inhibitors of IL6 receptor signaling and thus may contribute to the growth-inhibitory effect of FGFR3 signaling in cartilage.
Abstract (in Czech)
Aktivace FGFR3 vede k utlumení růstu chrupavky. Zjistili jsme, že FGF stimulus vede k akumulaci STAT1, 3, 5, 6, jak v modelu chondrocytárních buněk, tak v explantátech myších končetin. Přes tuto akumulaci bylo dokázáno, že signální dráhy STAT 1 a 3 nejsou funkční. FGF zvyšuje také expresi inhibitorů IL-6 signální dráhy CIS, SOCS1 a SOCS3, což může být jednou z příčin utlumení růstu chrupavky vlivem FGFR3 signálování.
Links
MSM0021622415, plan (intention)Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
PrintDisplayed: 24/4/2024 05:57