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@article{816480,
author = {Krejčí, Pavel and Procházková, Jiřina and Bryja, Vítězslav and Jelínková, Petra and Pejchalová, Kateřina and Kozubík, Alois and Tompson, Leslie Michels and Wilcox, William R.},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.cellsig.2008.10.006},
keywords = {fibroblast growth factor; cartilage; STAT1; STAT3; chondrocyte; cytokine; inhibition},
language = {eng},
issn = {0898-6568},
journal = {Cellular Signalling},
title = {Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes},
volume = {21},
year = {2009}
}
TY - JOUR
ID - 816480
AU - Krejčí, Pavel - Procházková, Jiřina - Bryja, Vítězslav - Jelínková, Petra - Pejchalová, Kateřina - Kozubík, Alois - Tompson, Leslie Michels - Wilcox, William R.
PY - 2009
TI - Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes
JF - Cellular Signalling
VL - 21
IS - 1
SP - 151-160
EP - 151-160
SN - 08986568
KW - fibroblast growth factor
KW - cartilage
KW - STAT1
KW - STAT3
KW - chondrocyte
KW - cytokine
KW - inhibition
N2 - Activation of FGFR3 leads to attenutation of cartilage growth. We evidence that FGF stimulus leads to accumulation of STAT1, 3, 5, 6 both in chondrocyte model and murine limb explant cultures. Despite this accummulation, STAT 1, and 3 signaling pathways are impaired by FGF. FGF increases also expression of CIS, SOCS1, and SOCS3, inhibitors of IL6 receptor signaling and thus may contribute to the growth-inhibitory effect of FGFR3 signaling in cartilage.
ER -
KREJČÍ, Pavel, Jiřina PROCHÁZKOVÁ, Vítězslav BRYJA, Petra JELÍNKOVÁ, Kateřina PEJCHALOVÁ, Alois KOZUBÍK, Leslie Michels TOMPSON a William R. WILCOX. Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. \textit{Cellular Signalling}. 2009, roč.~21, č.~1, s.~151-160. ISSN~0898-6568. Dostupné z: https://dx.doi.org/10.1016/j.cellsig.2008.10.006.
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