a 2008

HAPLOTYPE OF FOUR MMP2 GENE PROMOTER POLYMORPHISMS AS PROTECTION VARIANT FOR ISCHEMIC HEART DISEASE AHEAD OF PROGRESSION TO HEART FAILURE

PÁVKOVÁ GOLDBERGOVÁ, Monika, Martin POLOCZEK, Jiří PAŘENICA, Lenka ŠPINAROVÁ, Ladislav GROCH et. al.

Basic information

Original name

HAPLOTYPE OF FOUR MMP2 GENE PROMOTER POLYMORPHISMS AS PROTECTION VARIANT FOR ISCHEMIC HEART DISEASE AHEAD OF PROGRESSION TO HEART FAILURE

Name in Czech

Haplotyp čtyř MMP2 promotorových polymorfismů jako chranná varianta pro ischemickou chorobu srdeční

Authors

Edition

The 1st World Congress on Controversies in Cardiovascular Disease: Diagnosis, Treatment and Interventions (C-Care), 2008

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

Genetics and molecular biology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords in English

MMP2, gene, polymorphism

Tags

Tags

International impact

Abstract

V originále

The study detected differences in genotype distributions and/or alelle frequences of MMP2 -790G/T polymorphism between patients with chronic heart failure on base of IHD and IHD patients (Pg=0.001, OR=3.07; Pa=0.01). Further, highly significant association in haplotype frequences was observed between chronic heart failure on base of IHD and IHD patients (Pg=0.0014), with higer prevalence of GCGC haplotype within the CHF group (OR=29,51; P=0.000001).

Links

NR9356, research and development project
Name: Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI
Investor: Ministry of Health of the CR, Complex estimation of relation of MMP-1,2,3,9,TIMP-1 and ACE polymorphisms to left ventricuzlar remodelation and to medium-term prognosis after acute infarct myocardum with ST elevation treated by primary PCI