BRYJA, Vítězslav, Jiří PACHERNÍK, Jan VONDRÁČEK, Karel SOUČEK, Lukáš ČAJÁNEK, Viktor HORVÁTH, Zuzana HOLUBCOVÁ, Petr DVOŘÁK and Aleš HAMPL. Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin. Cell Proliferation. 2008, vol. 41, No 6, p. 875-93, 19 pp. ISSN 0960-7722.
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Basic information
Original name Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin
Name in Czech Liniově specifické složení komplexů cyklin D-CDK4/CDK6-p27 odhaluje jedinečné funkce CDK4, CDK6 a jednotlivých cyklinů typu D v diferencujících buňkách embryonálního původu
Authors BRYJA, Vítězslav (203 Czech Republic, guarantor, belonging to the institution), Jiří PACHERNÍK (203 Czech Republic, belonging to the institution), Jan VONDRÁČEK (203 Czech Republic, belonging to the institution), Karel SOUČEK (203 Czech Republic), Lukáš ČAJÁNEK (203 Czech Republic), Viktor HORVÁTH (703 Slovakia), Zuzana HOLUBCOVÁ (203 Czech Republic, belonging to the institution), Petr DVOŘÁK (203 Czech Republic, belonging to the institution) and Aleš HAMPL (203 Czech Republic, belonging to the institution).
Edition Cell Proliferation, 2008, 0960-7722.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.423
RIV identification code RIV/00216224:14110/08:00024436
Organization unit Faculty of Medicine
UT WoS 000261140200003
Keywords (in Czech) embryonální buňky
Keywords in English G1/S transition; cyclin D; embryonic cells differentiation
Tags cyclin D, embryonic cells differentiation, G1/S transition
Tags International impact
Changed by Changed by: Mgr. Jiří Pacherník, Ph.D., učo 6371. Changed: 26/3/2012 12:11.
Abstract
Using P19 embryonal carcinoma cells, which we induces to differentiate either to neural or endodermal lineage, we demonstrate that composition of crucial G1/S transition regulating complexes does not reflect only proliferation parameters. Cyclin D-Cdk4/Cdk6-p27 complexes dramatically change depending on the differentiation pathways, which suggests the these complexes also regulate differentiation.
Abstract (in Czech)
Na systému embryonální karcinomové linie P19, kterou diferencujeme buď do neurální nebo do endodermální linie, demonstrujeme, že složení komplexů, klíčových pro regulaci průchodu buněčným cyklem neodráží jen proliferační parametry. Komplexy cyklinů D/CDK4/6-p27 se dramaticky mění v závislosti na směru diferenciace, což ukazuje, že tyto komplexy se účastní i regulace diferenciace.
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