MAISNAR, Vladimír, Miloš TICHÝ, J. STULÍK, P. URBAN, Zdeněk ADAM, Eva KDLČKOVÁ, J. VÁVROVÁ, Vladimír PALIČKA, L. JEBAVÝ, R. KODET, Tomáš BÜCHLER and Roman HÁJEK. Capillary immunotyping electrophoresis and high resolution two-dimensional electrophoresis for the detection of mu-heavy chain disease. Clinica Chimica Acta. Amsterdam: Elsevier Science BV, 2008, vol. 389, 1-2, p. 171-173. ISSN 0009-8981. |
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@article{817663, author = {Maisnar, Vladimír and Tichý, Miloš and Stulík, J. and Urban, P. and Adam, Zdeněk and Kdlčková, Eva and Vávrová, J. and Palička, Vladimír and Jebavý, L. and Kodet, R. and Büchler, Tomáš and Hájek, Roman}, article_location = {Amsterdam}, article_number = {1-2}, keywords = {multiple myeloma;monoclonal immunoglobulin;immunofixation}, language = {eng}, issn = {0009-8981}, journal = {Clinica Chimica Acta}, title = {Capillary immunotyping electrophoresis and high resolution two-dimensional electrophoresis for the detection of mu-heavy chain disease.}, volume = {389}, year = {2008} }
TY - JOUR ID - 817663 AU - Maisnar, Vladimír - Tichý, Miloš - Stulík, J. - Urban, P. - Adam, Zdeněk - Kdlčková, Eva - Vávrová, J. - Palička, Vladimír - Jebavý, L. - Kodet, R. - Büchler, Tomáš - Hájek, Roman PY - 2008 TI - Capillary immunotyping electrophoresis and high resolution two-dimensional electrophoresis for the detection of mu-heavy chain disease. JF - Clinica Chimica Acta VL - 389 IS - 1-2 SP - 171-173 EP - 171-173 PB - Elsevier Science BV SN - 00098981 KW - multiple myeloma;monoclonal immunoglobulin;immunofixation N2 - Heavy chain disease with monoclonal incomplete mu-heavy chains (mu-HCD) is a rare disorder usually associated with an underlying lymphoproliferative malignancy. Laboratory diagnosis of patients with mu-HCD is usually challenging and the monoclonal protein is not detected by electrophoresis in up to 75% of mu-HCD cases. We describe a patient with multiple malignancies in whom we detected and characterized monoclonal mu-heavy chains using immunofixation electrophoresis, capillary zone electrophoresis with immunotyping, and high resolution two-dimensional electrophoresis. The high resolution 2D electrophoresis enabled us to determine the molecular weight of the mu-heavy chains. The abnormal protein concentration in the serum was unusually high, 38 g/l measured in our patient is the highest reported value in the literature so far. ER -
MAISNAR, Vladimír, Miloš TICHÝ, J. STULÍK, P. URBAN, Zdeněk ADAM, Eva KDLČKOVÁ, J. VÁVROVÁ, Vladimír PALIČKA, L. JEBAVÝ, R. KODET, Tomáš BÜCHLER and Roman HÁJEK. Capillary immunotyping electrophoresis and high resolution two-dimensional electrophoresis for the detection of mu-heavy chain disease. \textit{Clinica Chimica Acta}. Amsterdam: Elsevier Science BV, 2008, vol.~389, 1-2, p.~171-173. ISSN~0009-8981.
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